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||Rab27 is a small GTPase that belongs to the Ras superfamily. Rab proteins play an important role in various aspects of membrane traffic, including cargo selection, vesicle budding, vesicle motility, tethering, docking, and fusion. The monomeric GTPase Rab27 subfamily regulates the exocytosis of these cell-specific store organelles. Rab27 acts through organelle-specific effector proteins, such as granuphilin in pancreatic beta cells and melanophilin in melanocytes. The Rab27 and effector complex then interacts with proteins that are essential for membrane transport and fusion. The GST-Tag facilitates the protein's application in typical GST pull-down assays.
||For in vitro use only.
||Liquid. Supplied in 25 mM HEPES pH 7.2, 200 mM NaCl, 10 mM MgCl2, 10 μM GDP, 2 mM DTE and 10% glycerol.
||100 pmol of protein can bind > 80 pmol of GDP.
||≥ 90% by SDS-PAGE.
||Quality guaranteed for 12 months, store at -80℃. Avoid freeze / thaw cycles.