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Recombinant Human V-raf-1 Murine Leukemia Viral Oncogene Homolog 1

Cat. No. : RAF1-1122H
Description : Raf is a member of the serine/threonine proteine kinase family involved in regulation of cell growth and differentiation and is the most important effector of Ras. Full-length Raf is composed of three conserved regions responsible for interaction with Ras, for phosphorylation and for catalytic activity. RafRBD (Ras binding domain, amino acids 50-132) mediates interaction with membrane-anchored Ras necessary for activation of the kinase activity of Raf.
Source : E.coli.
Molecular Weight : 9.4 kDa (amino acids 50 - 132).
Form : Liquid. Supplied in 32 mM Tris-HCl pH 7.6, 200 mM NaCl, 5 mM MgCl2 and 5 mM DTT.
Purity : ≥95% by SDS-PAGE.
Usage : For in vitro use only.
Storage : Quality guaranteed for 12 months store at -80°C. Avoid freeze / thaw cycles.
Gene Name : RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 [ Homo sapiens ]
Synonyms : RAF1; v-raf-1 murine leukemia viral oncogene homolog 1; NS5; CRAF; Raf-1; c-Raf; Oncogene RAF1; raf proto-oncogene serine/threonine protein kinase; EC 2.7.11.1; C-RAF; cRaf
Gene ID : 5894
mRNA Refseq : NM_002880
Protein Refseq : NP_002871
MIM : 164760
UniProt ID : P04049
Chromosome Location : 3p25
Pathway : Acute myeloid leukemia; B cell receptor signaling pathway; Bladder cancer; Chemokine signaling pathway; Chronic myeloid leukemia; Colorectal cancer; Endometrial cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Focal adhesion; Gap junction; Glioma; GnRH signaling pathway; Insulin signaling pathway; Long-term depression; Long-term potentiation; MAPK signaling pathway; Melanogenesis; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Progesterone-mediated oocyte maturation; Prostate cancer; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway; VEGF signaling pathway; Vascular smooth muscle contraction
Function : ATP binding; metal ion binding; nucleotide binding; protein serine/threonine kinase activity; receptor signaling protein activity; transferase activity; zinc ion binding

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