Recombinant Human Heat Shock 22kDa Protein 8

• Cat.No.: HSPB8-1254H
• Product Overview: Recombinant Human Heat Shock Protein 22 was expressed inE.Coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: HSP22 displays temperature-dependent chaperone activity. HSP-22 acts as a mn(2+)-dependent serine-threonine- specific protein kinase. we are not convinced that this is its true role. Defects in HSPB8 are a cause of distal hereditary motor neuropathy type ii (DHMN2) also known as distal spinal muscular atrophy (DSMA) and spinal muscular atrophy of the charcot-marie-tooth type. it is an autosomal dominant disorder of lower motor neurons characterized by distal muscle weakness.
• Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Formulation: The HSP22 protein was lyophilized from a concentrated (1mg/ml) solution containing 20mM Tris-acetate, pH-7.6, 10mM NaCl, 0.1mM EDTA, 0.1mM PMSF, 15mMβ-ME.
• Solubility: It is recommended to reconstitute the lyophilized HSP22 in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
• Stability: Lyophilized HSP22 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution HSP22 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
• Immunological Activity: Immunoreactivity is confirmed by reaction with monoclonal mouse antibodies against HSP22.

Gene Information

• Gene Name: HSPB8 heat shock 22kDa protein 8 [ Homo sapiens ]
• Synonyms: heat shock 22kDa protein 8; H11; HMN2; CMT2L; DHMN2; E2IG1; HMN2A; HSP22; HSPB8; E2-induced gene 1; protein kinase H11; heat shock protein beta-8; heat shock 27kDa protein 8; small stress protein-like protein HSP22; HspB8; CRYAC; Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22
• Gene ID: 26353
• mRNA Refseq: NM_014365
• Protein Refseq: NP_055180
• MIM: 608014
• UniProt ID: Q9UJY1
• Chromosome Location: 12q24.23
• Function: protein serine/threonine kinase activity; identical protein binding