"MLH1" Related Products

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Recombinant Human MLH1

Cat. No.: MLH1-1306H
Product Overview: Recombinant Human MLH1(a.a. 557-756) expressed inE.coliis antibody reactive. The MLH1 is purified by proprietary chromatographic techniques.
Description: MLH1 is an 87kDa protein involved in mismatched nucleotides during DNA replication or repair process. Mutations in the human MLH1 (hMLH1) and hMLH2 genes contribute to the development of sporadic colorectal carcinoma and some other both hereditary and sporadic forms of human cancer. MLH1 is identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). MLH1 is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic modifications in microsatellite sequences (RER+ phenotype) found in HNPCC.
Source: Escherichia Coli.
Applications: • ELISA • Inhibition Assays • Western Blotting.
Physical Appearance: Sterile Filtered clear solution.
Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC (b) Analysis by SDS-PAGE.
Formulation: The MLH1 at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
Stability: Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.
Gene Name: MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) [ Homo sapiens ]
Synonyms: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); FCC2; COCA2; HNPCC; hMLH1; HNPCC2; MGC5172; MLH1; MutL protein homolog 1; DNA mismatch repair protein Mlh1; mutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2)
Gene ID: 4292
mRNA Refseq: NM_000249
Protein Refseq: NP_000240
MIM: 120436
UniProt ID: P40692
Chromosome Location: 3p21.3
Pathway: Colorectal cancer; Endometrial cancer; Mismatch repair; Pathways in cancer
Function: ATP binding; MutSalpha complex binding; guanine/thymine mispair binding; mismatched DNA binding; protein binding; single-stranded DNA binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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