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Recombinant Bovine PIK3CA

Cat. No.: PIK3CA-208B
Product Overview: Recombinant Bovine PIK3CA is expressed inSf9 insect cells.Phosphoinositide 3-kinase alpha is a glycosilated protein having a molecular weight as follows: p85a chain 83.5 kDa, p110 chain 124.3 kDa.
Description: PI3Ka plays a specific role in apoptosis in human colon cancer cells. Injection of neutralizing antibodies specific to PI3Ka into adenocarcinoma cells induced apoptosis, a response that was reverted by treating cells with caspase inhibitor. It was also shown that PI3Ka mediated phosphorylation of the p85a adapter reduces the lipid kinase activity of the heterodimer and this gives hints for PI3K-dependent signaling events not requiring production of 3'-phosphorylated phosphoinositides. PI3Ka is a key regulator of the initiation of keratinocyte differentiation. A decrease in PI3Ka activity results in a loss of keratinocyte adhesion to the extracellular membrane and the initiation of early phase differentiation.
Source: Sf9 insect cells.
Physical Appearance: Sterile filtered liquid formualtion.
Formulation: PI3Ka solution in 25mM HEPES, pH 8.0, 25mM NaCl, 2.5mM MgCl2 and 50% glycerol.
Stability: PI3Ka although stable at 14°C for 1 week, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Purity: Greater than 90.0% as determined by SDS-PAGE.
Activity: 1,000 U/mg.
Unit Definition: 1 unit is defined as 1 picomole phosphate transferred to PIP2 per minute.
Gene Name: PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide [ Bos taurus ]
Synonyms: PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide; Phosphoinositide 3-kinase alpha p110a/p85a, PI3Ka, 2.7.1.137, Phosphatidylinositol 3-kinase, 1-phosphatidylinositol 3-kinase, PI3-kinase, PtdIns-3-kinase, Type I phosphatidylinositol kinase, Type III phosphoinositide 3-kinase; EC 2.7.1.153
Gene ID: 282306
mRNA Refseq: NM_174574
Protein Refseq: NP_776999
UniProt ID: P32871
Pathway: Acute myeloid leukemia; Apoptosis; B cell receptor signaling pathway; Chemokine signaling pathway; Colorectal cancer; Endometrial cancer; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Focal adhesion; Inositol phosphate metabolism; Insulin signaling pathway; Jak-STAT signaling pathway; Leukocyte transendothelial migration; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Phosphatidylinositol signaling system; Progesterone-mediated oocyte maturation; Prostate cancer; Regulation of actin cytoskeleton; Small cell lung cancer; VEGF signaling pathway; mTOR signaling pathway
Function: 1-phosphatidylinositol-3-kinase activity; ATP binding; inositol or phosphatidylinositol kinase activity; insulin receptor substrate binding; nucleotide binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphotransferase activity, alcohol group as acceptor; transferase activity

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