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Recombinant Human Thrombospondin 1

Cat. No.: THBS1-185H
Product Overview: Recombinant Human Thrombospondin 1 is glycosylated with N-linked sugars and produced using baculovirus vectors ininsect cells. Recombinant Human THBS1 is Reactive with A4.1 anti-TSP mAb and its Mw is 140,000 Dalton.
Discription: Thrombospondin-1 (TSP1) is a member of the Thrombospondin family and is encoded by the gene THBS1 which is a subunit of a disulfide-linked homotrimeric protein. Thrombospondin-1 is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Thrombospondin-1 can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. TSP1 has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. TSP1 has been shown to be a natural inhibitor of neovascularization and tumorigenesis in healthy tissue. TSP1 interacts with no less than 12 cell adhesion receptors, including CD36, αv integrins, β1 integrins, syndecan, and integrin-associated protein (IAP or CD47). It also interacts with various proteases involved in angiogenesis, including plasminogen, urokinase, matrix metalloproteinase, thrombin, cathepsin, and elastase. Positive and negative modulation of endothelial cell adhesion, motility, and growth are attributed to TSP1. Recently, thrombospondin-1 was found to bind to the reelin receptors, ApoER2 and VLDLR, in so doing affecting neuronal migration in the rostral migratory stream.
Source: Baculovirus Insect Cells.
Physical Appearance: Sterile Filtered clear solution.
Formulation: The sterile protein solution contains 20mM Sodium phosphate, pH 6.0 and 300mM NaCl.
Purity: Greater than 90.0% as determined by:(a) Analysis by RP-HPLC; (b) Analysis by SDS-PAGE.
Storage: Recombinant Human TSP should be stored between 2°C- 8°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name: THBS1 thrombospondin 1 [ Homo sapiens ]
Synonyms: THBS1; thrombospondin 1; TSP1; THBS; TSP; THBS-1; TSP-1; thrombospondin-1p180
Gene ID: 7057
mRNA Refseq: NM_003246
Protein Refseq: NP_003237
MIM: 188060
UniProt ID: P07996
Chromosome Location: 15q15
Pathway: Bladder cancer; ECM-receptor interaction; Focal adhesion; TGF-beta signaling pathway; p53 signaling pathway
Function: calcium ion binding; collagen V binding; eukaryotic cell surface binding; fibrinogen binding; fibroblast growth factor 2 binding; fibronectin binding; heparin binding; identical protein binding; integrin binding; laminin binding; low-density lipoprotein binding; proteoglycan binding; structural molecule activity; transforming growth factor beta binding

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