Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human Activin A Receptor, Type I

Cat.No. : ACVR1-1408H
Product Overview : Recombinant human Activin A Receptor, Type I was expressed inInsect cells. MW=26 kDa.
  • Specification
  • Gene Information
  • Related Products
Cat. No. : ACVR1-1408H
Description : Human Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues, belonging to the TGF-β family. It exhibits a wide range of biological activity including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin.
Source : Insect cells.
Specific Activity : ≥5×10⁵ U/mg.
Product Format : Sterile filtered, lyophilized.
Stabilizer : None.
Purity : >95% (SDS-PAGE, HPLC).
Endotoxin Level : <0.1 ng/μg (1 EU/μg).
Buffer : Citric acid (10 mM, pH 3.0).
Biological Activity : The ED₅₀ of ≤2 ng/mL was determined by its ability to inhibit the proliferation of mouse MPC-11 cells. It corresponds to a specific activity of ≥5×10⁵ U/mg.
Reconstitution : We recommend a quick spin followed by reconstitution in deionized sterile-filtered water to a concentration of 50μg/mL. This solution can be stored at 4°C for 1 month or at –20°C for future use. It is recommended that further dilutions be made in PBS containing 2 mg/mL albumin and stored at –20°C.
Storage : The lyophilized protein is stable for a few weeks at room temperature, but best stored at –20°C for at least two years. Reconstituted Human Activin A should be stored in working aliquots at –20°C. Avoid repeated freeze-thaw cycles.
Gene Name : ACVR1 activin A receptor, type I [ Homo sapiens ]
Synonyms : ACVR1; activin A receptor, type I; FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2; OTTHUMP00000204604; OTT HUMP000002 04626; hydroxyalkyl-protein kinase; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1; EC 2.7.11.30
Gene ID : 90
mRNA Refseq : NM_001105
Protein Refseq : NP_001096
MIM : 102576
UniProt ID : Q04771
Chromosome Location : 2q23-q24
Pathway : Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
Function : ATP binding; SMAD binding; activin binding; activin receptor activity, type I; follistatin binding; gnesium ion binding; manganese ion binding; nucleotide binding; protein homodimerization activity; receptor activity; transferase activity; transforming growth factor beta binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All ACVR1 Products

Required fields are marked with *

My Review for All ACVR1 Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends