Recombinant Human Fas (TNF Receptor Ssuper Family, Member 6) FAS-1411H

Recombinant Human Fas (TNF Receptor Ssuper Family, Member 6)


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Recombinant Human Fas (TNF Receptor Ssuper Family, Member 6)

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Cat. No. : FAS-1411H
Product Overview : Recombinant, human soluble APO-1/Fas:Fc-IgG (aa.1-154) is produced in human embryo kidney cells. MW= 60 kDa.
Description : Apo-1 (Fas/CD95) is a 45 kD type I transmembrane protein belonging to the TNF receptor family. A subgroup of this receptor family called ”death receptors” contain 3-4 cysteine-rich repeats in the extracellular portion and a cystoplasmic motif called the ”death domain”, which is responsible for the transduction of the death signal. The death domain associates with FADD/MORT, which in turn connects to aspartate-specific proteases (Caspases) that are implicated as mediators of most types of apoptotic cell death (6-9).
Source : Human embryo kidney cells.
Presentation And Handling : sAPO-1/Fas is provided as lyophilized powder. Prepare a concentrated stock solution of APO-1/Fas:Fc-IgG (1 mg/ml in PBS) by dissolving the entire preparation (50 µg) in 50 µl sterile H2O. Further dilutions should be made with medium containing 5% fetal calf serum.
Purity : >95% pure as demonstrated by SDS-PAGE.
Biological Activity : Recombinant, human soluble APO-1/Fas:Fc-IgG inhibits the activity of APO-1/Fas ligand of human and mouse.
PDB rendering based on 1ddf. :

Gene Name : FAS Fas (TNF receptor superfamily, member 6) [ Homo sapiens ]
Synonyms : FAS; Fas (TNF receptor superfamily, member 6); APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; tumor necrosis factor receptor superfamily, member 6; Fas AMA; CD95 antigen; apoptosis antigen 1; APO-1 cell surface antigen
Gene ID : 355
mRNA Refseq : NM_000043
Protein Refseq : NP_000034
MIM : 134637
UniProt ID : P25445
Chromosome Location : 10q24.1
Pathway : Allograft rejection; Alzheimer"s disease; Apoptosis; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction; Graft-versus-host disease; MAPK signaling pathway; Natural killer cell mediated cytotoxicity; Type I diabetes mellitus; Apoptosis
Function : identical protein binding; kinase binding; transmembrane receptor activity

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