Recombinant Human Fas (TNF Receptor Ssuper Family, Member 6)
Cat.No. : | FAS-1411H |
Product Overview : | Recombinant, human soluble APO-1/Fas:Fc-IgG (aa.1-154) is produced in human embryo kidney cells. MW= 60 kDa. |
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- Gene Information
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Cat. No. : | FAS-1411H |
Description : | Apo-1 (Fas/CD95) is a 45 kD type I transmembrane protein belonging to the TNF receptor family. A subgroup of this receptor family called ”death receptors” contain 3-4 cysteine-rich repeats in the extracellular portion and a cystoplasmic motif called the ”death domain”, which is responsible for the transduction of the death signal. The death domain associates with FADD/MORT, which in turn connects to aspartate-specific proteases (Caspases) that are implicated as mediators of most types of apoptotic cell death (6-9). |
Source : | Human embryo kidney cells. |
Presentation And Handling : | sAPO-1/Fas is provided as lyophilized powder. Prepare a concentrated stock solution of APO-1/Fas:Fc-IgG (1 mg/ml in PBS) by dissolving the entire preparation (50 µg) in 50 µl sterile H2O. Further dilutions should be made with medium containing 5% fetal calf serum. |
Purity : | >95% pure as demonstrated by SDS-PAGE. |
Biological Activity : | Recombinant, human soluble APO-1/Fas:Fc-IgG inhibits the activity of APO-1/Fas ligand of human and mouse. |
Gene Name : | FAS Fas (TNF receptor superfamily, member 6) [ Homo sapiens ] |
Synonyms : | FAS; Fas (TNF receptor superfamily, member 6); APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; tumor necrosis factor receptor superfamily, member 6; Fas AMA; CD95 antigen; apoptosis antigen 1; APO-1 cell surface antigen |
Gene ID : | 355 |
mRNA Refseq : | NM_000043 |
Protein Refseq : | NP_000034 |
MIM : | 134637 |
UniProt ID : | P25445 |
Chromosome Location : | 10q24.1 |
Pathway : | Allograft rejection; Alzheimer"s disease; Apoptosis; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction; Graft-versus-host disease; MAPK signaling pathway; Natural killer cell mediated cytotoxicity; Type I diabetes mellitus; Apoptosis |
Function : | identical protein binding; kinase binding; transmembrane receptor activity |
Products Types
◆ Recombinant Protein | ||
FAS-4403H | Recombinant Human FAS Protein, His (Fc)-Avi-tagged | +Inquiry |
Fas-12R | Recombinant Rat Fas Protein, His (Fc)-Avi-tagged | +Inquiry |
FAS-3853H | Recombinant Human FAS Protein, GST-tagged | +Inquiry |
FAS-242H | Recombinant Human FAS Protein, His-tagged | +Inquiry |
FAS-1468R | Recombinant Rhesus Macaque FAS Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
FAS-1139RCL | Recombinant Rat FAS cell lysate | +Inquiry |
FAS-001CCL | Recombinant Cynomolgus FAS cell lysate | +Inquiry |
FAS-2185HCL | Recombinant Human FAS cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionFAS protein plays an important role in cell signaling, it can activate downstream signaling pathways, such as death signaling pathway and survival signaling pathway, by binding to its ligand and transmitting signals.
It can provide a reference for clinical practice and guide the diagnosis, treatment and prevention of diseases by detecting the expression level of FAS protein and understanding its mechanism of action.
FAS protein-related diseases can be prevented and treated by regulating the expression level of FAS protein and inhibiting its signaling pathway.
Gene knockout or knockdown techniques can be used to study the function and mechanism of action of FAS proteins. By knocking out or knocking down the FAS gene, changes in processes such as apoptosis and immune response can be observed to further understand its function and mechanism of action.
FAS protein can bind to its ligand, activate the death signaling pathway, and induce apoptosis.
The expression level and activity of FAS protein can be measured to predict the prognosis and development trend of certain diseases.
Customer Reviews (3)
Write a reviewWhen experimenting with FAS, the results are very reproducible.
The stability of FAS products allows them to cope with different experimental conditions and modes of operation.
FAS has high specific activity and can exert strong biological effect at low concentration.
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