"CROT" Related Products

Recombinant Human Carnitine O-octanoyltransferase, GST-tagged, Active

Cat. No. : CROT-287H
Product Overview : Recombinant human COT (30-397) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW= 70 kDa.
Description : COT is an oncogene that can activate both the MAP kinase and JNK kinase pathways. COT activates IkappaB kinases and induces the nuclear production of NF-kappaB. C-terminal catalytic domain of KSR2 associates with COT and KSR2 can negatively regulates the kinase activity of COT in vitro. Co-transfection of KSR2 with COT in cells lead to reduced COT-mediated ERK activation and COT-induced IL8 production in a dose-dependent manner.
Source : Sf9 insect cellsusing baculovirus.
Sequence : 30-397.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : CROT carnitine O-octanoyltransferase [ Homo sapiens ]
Synonyms : CROT; carnitine O-octanoyltransferase; COT; peroxisomal carnitine acyltransferase; peroxisomal carnitine octanoyltransferase; EC
Gene ID : 54677
mRNA Refseq : NM_001143935
Protein Refseq : NP_001137407
MIM : 606090
UniProt ID : Q9UKG9
Chromosome Location : 7q21
Pathway : Metabolism of lipids and lipoproteins
Function : acyltransferase activity; carnitine O-octanoyltransferase activity; transferase activity

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