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Recombinant Human MERTK, GST-tagged, Active

Cat. No.: MERTK-258H
Product Overview: Recombinant human c-MER (578-872) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag.
Description: c-MER is a tyrosine kinase and a member of the MER/AXL/TYRO3 receptor kinase family. The c-MER gene encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. Functional knockout of c-MER in mice shows the mice to have macrophages deficient in the clearance of apoptotic thymocytes thereby demonstrating the critical role for c-MER in the engulfment and efficient clearance of apoptotic cells. Defects in c-MER have been associated with retinitis pigmentosa, a phenotype that can be reversed by replacement of the c-MER gene product.
Source: Sf9 insect cells using baculovirus.
Sequence: 578-872.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: MERTK c-mer proto-oncogene tyrosine kinase [ Homo sapiens ]
Synonyms: MERTK; c-mer proto-oncogene tyrosine kinase; MER; RP38; c-mer; MGC133349; MER receptor tyrosine kinase; STK kinase; EC 2.7.10.1; Receptor tyrosine kinase MerTK; Proto-oncogene tyrosine-protein kinase MER
Gene ID: 10461
mRNA Refseq: NM_006343
Protein Refseq: NP_006334
MIM: 604705
UniProt ID: Q12866
Chromosome Location: 2q14.1
Pathway: Hemostasis; Signaling in Immune system
Function: ATP binding; nucleotide binding; protein binding; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity

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