"PRKCI" Related Products


Recombinant Human Protein Kinase C, Iota, GST-tagged, Active

Cat. No.: PRKCI-405H
Product Overview: Recombinant human full-length PKCiota was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=98 kDa.
Description: PKCι is a member of the protein kinase C family of serine-threonine kinases. The amino acid sequence of PKCι showed greatest homology to PKCzeta, with 72% identity overall rising to 84% in the catalytic domain. Protein kinase C iota (PKCι) has been implicated in Ras signaling and is a critical downstream effector of oncogenic Ras in the colonic epithelium. Transgenic mice expressing constitutively active PKCι in the colon are highly susceptible to carcinogen-induced colon carcinogenesis.
Source: Sf9 insect cells using baculovirus.
Sequence: Full-length.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: PRKCI protein kinase C, iota [ Homo sapiens ]
Synonyms: PRKCI; protein kinase C, iota; PKCI; DXS1179E; MGC26534; nPKC-iota; EC; Protein kinase C iota type; Atypical protein kinase C-lambda/iota; aPKC-lambda/iota; PRKC-lambda/iota
Gene ID: 5584
mRNA Refseq: NM_002740
Protein Refseq: NP_002731
UniProt ID: P41743
Chromosome Location: 3q26.3
MIM: 600539
Pathway: Tight junction; Signalling by NGF; Endocytosis; Insulin signaling pathway; Cell-cell adhesion systems
Function: ATP binding; protein kinase C activity; metal ion binding; nucleotide binding; transferase activity; zinc ion binding; phospholipid binding; protein binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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