"PRKCQ" Related Products

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Recombinant Human Protein Kinase C, Theta, GST-tagged, Active

Cat. No. : PRKCQ-408H
Product Overview : Recombinant full-length human PRKCQ was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=110 kDa.
Description : Protein Kinase C, theta (PKCθ) is important component in the intracellular signaling cascade. Recent studies have suggested that local accumulation of fat metabolites inside skeletal muscle may activate a serine kinase cascade involving PKC-theta leading to defects in insulin signaling and glucose transport in skeletal muscle. Insulin resistance plays a primary role in the development of type 2 diabetes and may be related to alterations in fat metabolism. PKC-theta is a crucial component mediating fat-induced insulin resistance in skeletal muscle and is a potential therapeutic target for the treatment of type 2 diabetes.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
PDB rendering based on 1xjd. :

Gene Name : PRKCQ protein kinase C, theta [ Homo sapiens ]
Synonyms : PRKCQ; protein kinase C, theta; PRKCT; MGC126514; MGC141919; nPKC-theta; Protein kinase C theta type; EC 2.7.11.13
Gene ID : 5588
mRNA Refseq : NM_006257
Protein Refseq : NP_006248
MIM : 600448
UniProt ID : Q04759
Chromosome Location : 10p15
Pathway : Adipocytokine signaling pathway; T cell receptor signaling pathway; Tight junction; Vascular smooth muscle contraction; Apoptosis; Signaling in Immune system
Function : ATP binding; calcium ion binding; nucleotide binding; protein kinase C activity; transferase activity; zinc ion binding

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