Recombinant Human TAK1-TAB1, GST-tagged, Active

• Cat.No.: TAK1-TAB1-440H
• Product Overview: Recombinant human proteins TAK1 (1-303) and TAB1 (437-end), linked by a small peptide (DFGGGGG), were expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 74 kDa.

Specification

• Cat. No.: TAK1-TAB1-440H
• Description: TAK1 is a serine/threonine protein kinase that mediates signaling by TGFβ and morphogenetic protein (BMP). In response to IL-1, TAK1 forms a kinase complex with TAB1 and this complex is required for the activation of nuclear factor kappa B (NfκB). TAK1 can also activate MAPK8/JNK and MAP2K4/MKK4 and thus play a role in the cell response to environmental stress. Tak1 is essential for thymocyte development and activation and deletion of TAK1 prevents maturation of single-positive thymocytes displaying CD4 or CD8. Thymocytes lacking TAK1 fail to activate NfκB and JNK and are prone to apoptosis upon stimulation.
• Source: Sf9 insect cells using baculovirus.
• Sequence: TAK1 (1-303) and TAB1 (437-end)), linked by a small peptide (DFGGGGG).
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: MAP3K7 mitogen-activated protein kinase kinase kinase 7 [ Homo sapiens ],MAP3K7IP1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1 [ Homo sapiens ]
• Synonyms: MAP3K7; mitogen-activated protein kinase kinase kinase 7; TAK1; MEKK7; TGF1a; TGF-beta activated kinase 1; transforming growth factor-beta-activated kinase 1; EC 2.7.11.25; OTTHUMP00000016870; OTTHUMP00000016871; OTTHUMP00000016872; OTTHUMP00000016873; TGF-beta-activated kinase 1; TAB1; 3"-Tab1; MGC57664; MAP3K7IP1; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; TAK1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1
• Gene ID: 688510454
• mRNA Refseq: NM_003188NM_006116
• Protein Refseq: NP_003179NP_006107
• MIM: 602614602615
• UniProt ID: O43318Q15750
• Chromosome Location: 6q16.1-q16.322q13.1
• Pathway: Adherens junction; MAPK signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Wnt signaling pathway
• Function: ATP binding; MAP kinase kinase activity; MAP kinase kinase kinase activity; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity; catalytic activity; kinase activator activity