"ULK1" Related Products

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Recombinant Human Unc-51-Like Kinase 1 (C. elegans), GST-tagged, Active

Cat. No.: ULK1-255H
Product Overview: Recombinant human ULK1 (1-649) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW = 125 kDa.
Description: ULK1 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein. Knockdown of ULK1 inhibits the autophagic response as well as inhibiting rapamycin-induced autophagy consistent with a role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy. Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.
Source: Sf9 insect cells using baculovirus.
Sequence: 1-649.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: ULK1 unc-51-like kinase 1 (C. elegans) [ Homo sapiens ]
Synonyms: unc-51-like kinase 1 (C. elegans); ATG1; UNC51; Unc51.1; FLJ38455; FLJ46475; ULK1; Unc-51-like kinase 1; ATG1 autophagy related 1 homolog; EC 2.7.11.1; KIAA0722; unc-51 (C. elegans)-like kinase 1
Gene ID: 8408
mRNA Refseq: NM_003565
Protein Refseq: NP_003556
MIM: 603168
UniProt ID: O75385
Chromosome Location: 12q24.3
Pathway: Regulation of autophagy; mTOR signaling pathway
Function: ATP binding; nucleotide binding; protein complex binding; protein serine/threonine kinase activity; transferase activity

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