"PTPN13" Related Products


Recombinant Human PTPN13,GST-tagged,Active

Cat. No. : PTPN13-463H
Product Overview : Recombinant human PTPN13 (2169-2485) was expressed inE.colicells using a N-terminal GST tag. MW=61kDa.
Description : PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN13 is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. PTPN13 binds to a negative regulatory domain in Fas that inhibits Fas-induced apoptosis.
Source : E.coli.
Sequence : 2169-2485.
Applications : Phosphatase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
PDB rendering based on 1d5g. :

Gene Name : PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) [ Homo sapiens ]
Synonyms : PTPN13; protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase); PNP1; FAP-1; PTP1E; PTPL1; PTPLE; PTP-BL; PTP-BAS; DKFZp686J1497; Tyrosine-protein phosphatase non-receptor type 13; EC; Protein-tyrosine phosphatase 1E; PTP-E1; hPTPE1; Protein-tyrosine phosphatase PTPL1; Fas-associated protein-tyrosine phosphatase 1
Gene ID : 5783
mRNA Refseq : NM_006264
Protein Refseq : NP_006255
UniProt ID : Q12923
Chromosome Location : 4q21.3
MIM : 600267
Function : hydrolase activity; protein binding; protein tyrosine phosphatase activity

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