"PDE5A" Related Products

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Recombinant Human PDE5A, GST-tagged, Active

Cat. No.: PDE5A-479H
Product Overview: Recombinant human PDE5A (537-end) was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 63 kDa.
Description: PDE5A is a member of the cyclic nucleotide phosphodiesterase family. PDE5A is a cGMP-specific phosphodiesterase and hydrolyzes cGMP to 5"-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. PDE5A regulates nitric oxide (NO)-induced relaxation and cGMP breakdown in smooth muscle cells in vas deferens. PDE5A expression predisposes mice to adverse left ventricular remodeling after myocardial infarction. Furthermore, increased myocardial PDE5A expression in patients with advanced cardiomyopathy can contribute to the development of heart failure.
Source: Sf9 insect cells using baculovirus.
Sequence: 537-end.
Applications: PDE Assay.
Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: PDE5A phosphodiesterase 5A, cGMP-specific [ Homo sapiens ]
Synonyms: PDE5A; phosphodiesterase 5A, cGMP-specific; CN5A; PDE5; PDE5A1; CGB-PDE; cGMP-binding cGMP-specific 3",5"-cyclic nucleotide phosphodiesterase; EC 3.1.4.35; cGMP-binding cGMP-specific phosphodiesterase; phosphodiesterase 5A; cGMP-specific 3",5"-cyclic phosphodiesterase
Gene ID: 8654
mRNA Refseq: NM_001083
Protein Refseq: NP_001074
MIM: 603310
UniProt ID: O76074
Chromosome Location: 4q25-q27
Pathway: Progesterone-mediated oocyte maturation; Purine metabolism
Function: 3",5"-cyclic-GMP phosphodiesterase activity; cGMP binding; hydrolase activity; magnesium ion binding; nucleotide binding; zinc ion binding

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