Recombinant Human GNAQ

• Cat.No.: ADRB2-30059TH
• Product Overview: Recombinant Full length Human ADRB2 with N terminal FLAG tag and C terminal His tag, fused to the N terminal Human Gqα expressed in Sf9 insect cells.

Specification

• Description: This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
• Conjugation: FLAG,His
• Biological activity: Activity:3.4-12.3 pmol/mg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: ADRB2 adrenergic, beta-2-, receptor, surface [ Homo sapiens ]
• Official Symbol: ADRB2
• Synonyms: ADRB2; adrenergic, beta-2-, receptor, surface; ADRB2R; beta-2 adrenergic receptor; ADRBR; B2AR; BAR
• Gene ID: 154
• mRNA Refseq: NM_000024
• Protein Refseq: NP_000015
• Uniprot ID: P07550
• Chromosome Location: 5q31-q32
• Pathway: Adrenoceptors, organism-specific biosystem; Amine ligand-binding receptors, organism-specific biosystem; Arf6 signaling events, organism-specific biosystem; Arf6 trafficking events, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem
• Function: G-protein coupled receptor activity; adenylate cyclase binding; adrenergic receptor activity; beta2-adrenergic receptor activity; dopamine binding