Recombinant Human BCL2, His-tagged

• Cat.No.: BCL2-27441TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1-218 of Human Bcl2, non-glycosylated with His-tag.

Specification

• Description: This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Expressed in a variety of tissues.
• Form: Lyophilised:Resuspend product in 100ul of 10% Acetic acid (Glacial), over night at 4°C.
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 250mM Sodium chloride, 10mM Tris HCl, 1mM EDTA, pH 8
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the Bcl-2 family.

Gene Information

• Gene Name: BCL2 B-cell CLL/lymphoma 2 [ Homo sapiens ]
• Official Symbol: BCL2
• Synonyms: BCL2; B-cell CLL/lymphoma 2; apoptosis regulator Bcl-2; Bcl 2; PPP1R50; protein phosphatase 1; regulatory subunit 50
• Gene ID: 596
• mRNA Refseq: NM_000633
• Protein Refseq: NP_000624
• Uniprot ID: P10415
• Chromosome Location: 18q21.3
• Pathway: ATF-2 transcription factor network, organism-specific biosystem; Activation of BAD and translocation to mitochondria, organism-specific biosystem; Activation of BH3-only proteins, organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem
• Function: BH3 domain binding; channel activity; identical protein binding; protease binding; protein binding