Recombinant Human CD82

• Cat.No.: CD82-27889TH
• Product Overview: Recombinant full length Human CD82 with N terminal proprietary tag; Predicted MWt 55.11 kDa.

Specification

• Description: This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
• Protein length: 267 amino acids
• Molecular Weight: 55.110kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Lymphoid specific.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MGSACIKVTKYFLFLFNLIFFILGAVILGFGVWILADKSS FISVLQTSSSSLRMGAYVFIGVGAVTMLMGFLGCIGAVNE VRCLLGLYFAFLLLILIAQVTAGALFYFNMGKLKQEMGGI VTELIRDYNSSREDSLQDAWDYVQAQVKCCGWVSFYNWTD NAELMNRPEVTYPCSCEVKGEEDNSLSVRKGFCEAPGNRT QSGNHPEDWPVYQEGCMEKVQAWLQENLGIILGVGVGVAI VELLGMVLSICLCRHVHSEDYSKVPKY
• Sequence Similarities: Belongs to the tetraspanin (TM4SF) family.

Gene Information

• Gene Name: CD82 CD82 molecule [ Homo sapiens ]
• Official Symbol: CD82
• Synonyms: CD82; CD82 molecule; CD82 antigen , KAI1, kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and IA4)) , ST6; CD82 antigen; IA4; R2; R2 leukocyte antigen; suppression of tumorigenicit
• Gene ID: 3732
• mRNA Refseq: NM_001024844
• Protein Refseq: NP_001020015
• MIM: 600623
• Uniprot ID: P27701
• Chromosome Location: 11p11.2
• Pathway: Direct p53 effectors, organism-specific biosystem; p53 signaling pathway, organism-specific biosystem; p53 signaling pathway, conserved biosystem
• Function: protein binding