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Recombinant Human TGFBR1, GST-tagged

Cat.No. : TGFBR1-1499H
Product Overview : Recombinant human TGFbetaR1 (80-end) was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 65 kDa.
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  • Gene Information
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Cat. No. : TGFBR1-1499H
Description : TGFβR1 is a transmembrane serine/threonine protein kinase and a member of the TGFβ receptor subfamily. TGFβ regulates cell cycle progression by a unique signaling mechanism that involves its binding to TGFβR2 and activation of TGFβR1. TGFβR1 may be inactivated in many of the cases of human tumor cells refractory to TGFβ-mediated cell cycle arrest. Heterozygous mutations in TGFβR1 and TGFβR2 have been reported in Loeys-Dietz aortic aneurysm syndrome (LDS) and also dominant TGFβR2 mutations have been identified in Marfan syndrome type 2 (MFS2) and familial thoracic aortic aneurysms and dissections (TAAD). Mutations of TGFβR1 and TGFβR2 are associated with atherosclerosis and several human cancers.
Source : Sf9 insect cells using baculovirus.
Sequence : 80-end.
Applications : Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : TGFBR1 transforming growth factor, beta receptor 1 [ Homo sapiens ]
Synonyms : TGFBR1; transforming growth factor, beta receptor 1; AAT5; ALK5; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4; 9q22; activin receptor-like kinase 5; transforming growth factor beta receptor I; serine/threonine-protein kinase receptor R4; activin A receptor type II-like kinase, 53Kd; activin A receptor type II-like kinase, 53kDa; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); EC 2.7.11.30; TGF-beta receptor type-1; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TGF-beta type I receptor; TbetaR-I; OTTHUMP00000021783
Gene ID : 7046
mRNA Refseq : NM_001130916
Protein Refseq : NP_001124388
MIM : 190181
UniProt ID : P36897
Chromosome Location : 9q22
Pathway : Adherens junction; Chronic myeloid leukemia; Colorectal cancer; Cytokine-cytokine receptor interaction; Endocytosis; MAPK signaling pathway; Pancreatic cancer; Pathways in cancer; TGF-beta signaling pathway
Function : ATP binding; SMAD binding; magnesium ion binding; manganese ion binding; nucleotide binding; protein complex binding; protein heterodimerization activity; protein serine/threonine kinase activity; receptor activity; transferase activity; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; type II transforming growth factor beta receptor binding; ubiquitin protein ligase binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How can the information of TGFBR1 be used for the development of therapeutic strategies? 04/12/2022

In-depth study of the signaling pathways and regulatory mechanisms of TGFBR1 can provide important clues for the development of therapeutic strategies for related diseases.

Are gene polymorphisms in TGFBR1 associated with disease susceptibility? 09/11/2021

Gene polymorphisms in TGFBR1 may be associated with susceptibility to some diseases, such as heart disease and diabetes.

Is TGFBR1 associated with diseases of the skeletal system? 04/13/2021

Yes, TGFBR1 regulates the proliferation and differentiation of osteocytes in the skeletal system and has been implicated in diseases of the skeletal system.

What is the role of the TGFBR1 pathway in liver disease? 12/12/2020

The TGFBR1 pathway is involved in a variety of pathological processes in liver diseases, such as fibrosis and the occurrence of liver cancer.

What are the inhibitors of TGFBR1? 08/01/2020

Some inhibitors of TGFBR1 have been developed, such as LY2157299 and SD-208.

What is the relationship between TGFBR1 and kidney disease? 05/29/2020

TGFBR1 may play a role in regulating glomerular injury, fibrosis and renal failure in kidney disease.

Customer Reviews (3)

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Reviews
07/19/2021

    Easy to purify and high purity in production.

    04/22/2021

      The protein has strong reducibility.

      02/17/2021

        He did well in the ELISA test.

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