Recombinant Human TGFBR1, GST-tagged
Cat.No. : | TGFBR1-1499H |
Product Overview : | Recombinant human TGFbetaR1 (80-end) was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 65 kDa. |
- Specification
- Gene Information
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Cat. No. : | TGFBR1-1499H |
Description : | TGFβR1 is a transmembrane serine/threonine protein kinase and a member of the TGFβ receptor subfamily. TGFβ regulates cell cycle progression by a unique signaling mechanism that involves its binding to TGFβR2 and activation of TGFβR1. TGFβR1 may be inactivated in many of the cases of human tumor cells refractory to TGFβ-mediated cell cycle arrest. Heterozygous mutations in TGFβR1 and TGFβR2 have been reported in Loeys-Dietz aortic aneurysm syndrome (LDS) and also dominant TGFβR2 mutations have been identified in Marfan syndrome type 2 (MFS2) and familial thoracic aortic aneurysms and dissections (TAAD). Mutations of TGFβR1 and TGFβR2 are associated with atherosclerosis and several human cancers. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | 80-end. |
Applications : | Western Blot. |
Storage And Stability : | Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | TGFBR1 transforming growth factor, beta receptor 1 [ Homo sapiens ] |
Synonyms : | TGFBR1; transforming growth factor, beta receptor 1; AAT5; ALK5; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4; 9q22; activin receptor-like kinase 5; transforming growth factor beta receptor I; serine/threonine-protein kinase receptor R4; activin A receptor type II-like kinase, 53Kd; activin A receptor type II-like kinase, 53kDa; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); EC 2.7.11.30; TGF-beta receptor type-1; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TGF-beta type I receptor; TbetaR-I; OTTHUMP00000021783 |
Gene ID : | 7046 |
mRNA Refseq : | NM_001130916 |
Protein Refseq : | NP_001124388 |
MIM : | 190181 |
UniProt ID : | P36897 |
Chromosome Location : | 9q22 |
Pathway : | Adherens junction; Chronic myeloid leukemia; Colorectal cancer; Cytokine-cytokine receptor interaction; Endocytosis; MAPK signaling pathway; Pancreatic cancer; Pathways in cancer; TGF-beta signaling pathway |
Function : | ATP binding; SMAD binding; magnesium ion binding; manganese ion binding; nucleotide binding; protein complex binding; protein heterodimerization activity; protein serine/threonine kinase activity; receptor activity; transferase activity; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; type II transforming growth factor beta receptor binding; ubiquitin protein ligase binding |
Products Types
◆ Recombinant Protein | ||
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TGFBR1-143H | Active Recombinant Human TGFBR1 protein(Thr200-Met503), His&GST-tagged | +Inquiry |
Tgfbr1-1777M | Active Recombinant Mouse Tgfbr1 Protein, Fc-tagged | +Inquiry |
TGFBR1-1293H | Recombinant Human TGFBR1 Protein (T200-M503), Tag Free | +Inquiry |
◆ Lysates | ||
TGFBR1-2482HCL | Recombinant Human TGFBR1 cell lysate | +Inquiry |
TGFBR1-001HCL | Recombinant Human TGFBR1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIn-depth study of the signaling pathways and regulatory mechanisms of TGFBR1 can provide important clues for the development of therapeutic strategies for related diseases.
Gene polymorphisms in TGFBR1 may be associated with susceptibility to some diseases, such as heart disease and diabetes.
Yes, TGFBR1 regulates the proliferation and differentiation of osteocytes in the skeletal system and has been implicated in diseases of the skeletal system.
The TGFBR1 pathway is involved in a variety of pathological processes in liver diseases, such as fibrosis and the occurrence of liver cancer.
Some inhibitors of TGFBR1 have been developed, such as LY2157299 and SD-208.
TGFBR1 may play a role in regulating glomerular injury, fibrosis and renal failure in kidney disease.
Customer Reviews (3)
Write a reviewEasy to purify and high purity in production.
The protein has strong reducibility.
He did well in the ELISA test.
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