"MAPT" Related Products


Recombinant Human Microtubule-Associated Protein Tau

Cat. No. : MAPT-1572H
Product Overview : Recombinant human full-length tag-free Tau-352 Protein was expressed inE. coli.MW=49kDa.
Description : Tau-352 or Tau-A is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules. Deposits of Alzheimer"s disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, β-amyloid precursor protein (βAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system.
Source : E. coli.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : MAPT microtubule-associated protein tau [ Homo sapiens ]
Synonyms : MAPT; microtubule-associated protein tau; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; FLJ31424; MGC138549; microtubule-associated protein tau, isoform 4; G protein beta1/gamma2 subunit-interacting factor 1; Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau
Gene ID : 4137
mRNA Refseq : NM_001123066
Protein Refseq : NP_001116538
UniProt ID : P10636
Chromosome Location : 17q21.1
MIM : 157140
Pathway : Alzheimer"s disease; MAPK signaling pathway; Apoptosis
Function : axon; cell projection; cytoplasm; cytoskeleton; growth cone; microtubule; microtubule associated complex; plasma membrane; tubulin complex

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