Native Human EGF

Cat.No.: EGF-26462TH
Product Overview: Full length protein (Human) protein having a single, glycosylated, polypeptide chain containing 51 amino acids. M.Wt 6 kDa.Source: Pichia Pastoris.
Description: This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.
Tissue specificity: Expressed in kidney, salivary gland, cerebrum and prostate.
Form: Lyophilised:It is recommended to reconstitute the lyophilized Epidermal Growth Factor in sterile water to not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 150mM Sodium chloride, 25mM Sodium bicarbonate, pH 7.5
Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: The sequence of the first five N-terminal amino acids was determined and was found to be Asn-Ser-Asp-Ser-Glu, which agrees with the sequence of native human EGF. N-terminal methionine has been completely removed enzymatically.
Sequence Similarities: Contains 9 EGF-like domains.Contains 9 LDL-receptor class B repeats.
Gene Name: EGF epidermal growth factor [ Homo sapiens ]
Official Symbol: EGF
Synonyms: EGF; epidermal growth factor; epidermal growth factor (beta urogastrone); pro-epidermal growth factor;
Gene ID: 1950
mRNA Refseq: NM_001178130
Protein Refseq: NP_001171601
MIM: 131530
Uniprot ID: P01133
Chromosome Location: 4q25
Pathway: Arf6 signaling events, organism-specific biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Ceramide signaling pathway, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem;
Function: calcium ion binding; epidermal growth factor receptor binding; growth factor activity; protein binding; transmembrane receptor protein tyrosine kinase activator activity;

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