Species : |
Human |
Source : |
E.coli |
Tag : |
His |
Protein Length : |
138-586 a.a. |
Description : |
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. |
Conjugation : |
HIS |
Tissue specificity : |
Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component |
Form : |
Lyophilised:Reconstitute with 74 μl aqua dest. |
Storage buffer : |
Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5 |
Storage : |
Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : |
NKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHA EHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTD LWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDK KFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELY MRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKR RETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQI QRALQLEEERKRAQEEAERLEADRMAALRAKEELERQA VDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEW QHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSY HVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEA EKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL |
Sequence Similarities : |
Contains 1 FERM domain. |