Recombinant Human EZR, His-tagged

• Cat.No.: EZR-26818TH
• Product Overview: Recombinant fragment, corresponding to amino acids 138-586 of Human Ezrin with N terminal His tag; Predicted MWt 55kDa.

Specification

• Description: The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component
• Form: Lyophilised:Reconstitute with 74 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: NKEVHKSGYLSSERLIPQRVMDQHK LTRDQWEDRIQVWHA EHRGMLKDNAMLEYLKIAQDLEMYG INYFEIKNKKGTD LWLGVDALGLNIYEKDDKLTPKIGF PWSEIRNISFNDK KFVIKPIDKKAPDFVFYAPRLRINK RILQLCMGNHELY MRRRKPDTIEVQQMKAQAREEKHQK QLERQQLETEKKR RETVEREKEQMMREKEELMLRLQDY EEKTKKAERELSEQI QRALQLEEERKRAQEEAERLEADRM AALRAKEELERQA VDQIKSQEQLAAELAEYTAKIALLE EARRRKEDEVEEW QHRAKEAQDDLVKTKEELHLVMTAP PPPPPPVYEPVSY HVQESLQDEGAEPTGYSAELSSEGI RDDRNEEKRITEA EKNERVQRQLLTLSSELSQARDENK RTHNDIIHNENMRQGRDKYKTLRQI RQGNTKQRIDEFEAL
• Sequence Similarities: Contains 1 FERM domain.

Gene Information

• Gene Name: EZR ezrin [ Homo sapiens ]
• Official Symbol: EZR
• Synonyms: EZR; ezrin; VIL2, villin 2 (ezrin); cytovillin 2
• Gene ID: 7430
• mRNA Refseq: NM_001111077
• Protein Refseq: NP_001104547
• MIM: 123900
• Uniprot ID: P15311
• Chromosome Location: 6q25.3
• Pathway: Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; FAS (CD95) signaling pathway, organism-specific biosystem; Gastric acid secretion, organism-specific biosystem; Gastric acid secretion, conserved biosystem
• Function: actin filament binding; cell adhesion molecule binding; cytoskeletal protein binding; protein binding