Recombinant Human FGF5

• Cat.No.: FGF5-28880TH
• Product Overview: Recombinant Human FGF-5, a 27.6 kDa protein consisting of 252 amino acid residues.

Specification

• Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Source: E. coli
• Tissue specificity: Expressed in neonatal brain.
• Form: Lyophilised:Centrifuge the vial prior to opening.Reconstitute in 1x PBS, pH 7.2 to a concentration of 0.5–1.0 mg/ml.This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use.Repeated freeze thaw cycl
• Purity: >95% by SDS-PAGE
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: MAWAHGEKRL APKGQPGPAA TDRNPIGSSS RQSSSSAMSS SSASSSPAAS LGSQGSGLEQ SSFQWSPSGR RTGSLYCRVG IGFHLQIYPD GKVNGSHEAN MLSVLEIFAV SQGIVGIRGV FSNKFLAMSK KGKLHASAKF TDDCKFRERF QENSYNTYAS AIHRTEKTGR EWYVALNKRG KAKRGCSPRV KPQHISTHFL PRFKQSEQPE LSFTVTVPEK KNPPSPIKSK IPLSAPRKNT NSVKYRLKFR FG
• Sequence Similarities: Belongs to the heparin-binding growth factors family.

Gene Information

• Gene Name: FGF5 fibroblast growth factor 5 [ Homo sapiens ]
• Official Symbol: FGF5
• Synonyms: FGF5; fibroblast growth factor 5
• Gene ID: 2250
• mRNA Refseq: NM_004464
• Protein Refseq: NP_004455
• MIM: 165190
• Uniprot ID: P12034
• Chromosome Location: 4q21
• Pathway: Downstream signaling of activated FGFR, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR1 ligand binding and activation, organism-specific biosystem; FGFR1c ligand binding and activation, organism-specific biosystem; FGFR2 ligand binding and activation, organism-specific biosystem
• Function: fibroblast growth factor receptor binding; growth factor activity; protein tyrosine kinase activity