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Recombinant Mouse CD86 Antigen

Cat. No. : Cd86-1706M
Description : B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant costimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20 - 100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be up-regulated through interferon γ. B7-1 and B7-2 are both members of the immunoglobulin superfamily. Human B7-2 and B7-1 share 26% amino acid identity. Human and mouse B7-2 share 50% amino acid identity. However, it has been observed that both human and mouse B7-1 and B7-2 can bind to either human or mouse CD28 and CTLA-4, suggesting that there are conserved amino acids which form the B7-1/B7-2/CD28/CTLA-4 critical binding sites.
Molecular Weight : The predicted molecular weight of Recombinant Mouse B7-2 is Mr 51.8 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 60-65 kDa.
Source : Sf 21 Insect Cells.
State Of Matter : Lyophilized.
Purity : >95% by SDS Page and analyzed by silver stain.
Endotoxin : <0.1 ng per 1 µg as determined by the LAL method.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : Cd86 CD86 antigen [ Mus musculus ]
Synonyms : Cd86; CD86 antigen; B7; B70; MB7; B7-2; B7.2; CLS1; Ly58; ETC-1; Ly-58; MB7-2; Cd28l2; TS/A-2; OTTMUSP00000015940; activation B7-2 antigen; T-lymphocyte activation antigen CD86; early T cell costimulatory molecule-1
Gene ID : 12524
mRNA Refseq : NM_019388
Protein Refseq : NP_062261
UniProt ID : P42082
Chromosome Location : 16 26.9 cM
Pathway : Allograft rejection; Autoimmune thyroid disease; Cell adhesion molecules (CAMs); Graft-versus-host disease; Systemic lupus erythematosus; Toll-like receptor signaling pathway; Type I diabetes mellitus
Function : receptor activity

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