"CDH1" Related Products

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Recombinant Human Cadherin 1, Type 1, E-Cadherin (Epithelial)

Cat. No.: CDH1-1605H
Description: Cadherin 1, type 1, E-cadherin (epithelial), also known as CDH1 and CD32, is a tumor suppressor gene. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. E-cadherin-mediated cell-cell adhesion pathway may represent a novel chemotherapeutic target for bladder cancer, prostate cancer, and renal-cell carcinoma.
Source: NSO cells.
Molecular Weight: The predicted molecular weight of Recombinant Human E-Cadherin is 87.7 kDa. However, the actual molecular weight as observed by migration on SDS Page is 120 kDa.
State Of Matter: Lyophilized.
Purity: >90% by SDS Page and analyzed by silver stain.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Storage: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: CDH1 cadherin 1, type 1, E-cadherin (epithelial) [ Homo sapiens ]
Synonyms: CDH1; cadherin 1, type 1, E-cadherin (epithelial); UVO; CDHE; ECAD; LCAM; Arc-1; CD324; cadherin 1, type 1; uvomorulin; cell-CAM 120/80; cadherin 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial; uvomorulin; Cadherin-1; E-cadherin; CAM 120/80; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Uvomorulin; CD324 antigen; Epithelial cadherin
Gene ID: 999
mRNA Refseq: NM_004360
Protein Refseq: NP_004351
MIM: 192090
UniProt ID: P12830
Chromosome Location: 16q22.1
Pathway: Adherens junction; Bladder cancer; Cell adhesion molecules (CAMs); Endometrial cancer; Melanoma; Pathogenic Escherichia coli infection - EHEC; Pathways in cancer; Thyroid cancer; Apoptosis; Cell-cell adhesion systems; Integrin cell surface interactions; Signaling in Immune system
Function: RPTP-like protein binding; beta-catenin binding; calcium ion binding; cell adhesion molecule binding; protein phosphatase binding; transcription activator activity

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