Recombinant Human Cadherin 1, Type 1, E-Cadherin (Epithelial)

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Recombinant Human Cadherin 1, Type 1, E-Cadherin (Epithelial)

CDH1 Related Products

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Cat. No. : CDH1-1605H
Description : Cadherin 1, type 1, E-cadherin (epithelial), also known as CDH1 and CD32, is a tumor suppressor gene. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. E-cadherin-mediated cell-cell adhesion pathway may represent a novel chemotherapeutic target for bladder cancer, prostate cancer, and renal-cell carcinoma.
Source : NSO cells.
Molecular Weight : The predicted molecular weight of Recombinant Human E-Cadherin is 87.7 kDa. However, the actual molecular weight as observed by migration on SDS Page is 120 kDa.
State Of Matter : Lyophilized.
Purity : >90% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Storage : This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
PDB rendering based on 1i7w. :

Gene Name : CDH1 cadherin 1, type 1, E-cadherin (epithelial) [ Homo sapiens ]
Synonyms : CDH1; cadherin 1, type 1, E-cadherin (epithelial); UVO; CDHE; ECAD; LCAM; Arc-1; CD324; cadherin 1, type 1; uvomorulin; cell-CAM 120/80; cadherin 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial; uvomorulin; Cadherin-1; E-cadherin; CAM 120/80; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Uvomorulin; CD324 antigen; Epithelial cadherin
Gene ID : 999
mRNA Refseq : NM_004360
Protein Refseq : NP_004351
MIM : 192090
UniProt ID : P12830
Chromosome Location : 16q22.1
Pathway : Adherens junction; Bladder cancer; Cell adhesion molecules (CAMs); Endometrial cancer; Melanoma; Pathogenic Escherichia coli infection - EHEC; Pathways in cancer; Thyroid cancer; Apoptosis; Cell-cell adhesion systems; Integrin cell surface interactions; Signaling in Immune system
Function : RPTP-like protein binding; beta-catenin binding; calcium ion binding; cell adhesion molecule binding; protein phosphatase binding; transcription activator activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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