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Recombinant Human Ciliary Neurotrophic Factor Receptor

Cat. No.: CNTFR-1596H
Product Overview: Recombinant human CNTFR encoding the amino acid residues 1-346 was inserted into a baculovirus expression vector and expressed inSf 21 insect cells.
Description: Ciliary neurotrophic factor receptor alpha (CNTF Rα) is anchored to the cell membrane by a glycosyl-phosphatidylinositol linkage and is expressed exclusively in the nervous system and skeletal muscle. One possible function of this type of linkage is to allow for the regulated release of this receptor component. Potential physiological roles for the soluble CNTF receptor alpha subunit are suggested by its presence in cerebrospinal fluid and by its release from skeletal muscle in response to peripheral nerve injury.
Molecular Weight: The predicted molecular weight of Recombinant Human CNTF sRα is Mr 36 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 52 kDa.
Source: Sf 21 Insect Cells.
State Of Matter: Lyophilized.
Purity: >97% by SDS Page and analyzed by silver stain.
Formulation: This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Biological Activity: The biological activity of Human CNTF sRα was determined by its ability to enhance hCNTF-dependent TF-1 cell proliferation. The expected ED50 for this effect is typically 0.2 - 0.4 μg/mL in the presence of 20 ng/mL of rhCNTF.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: CNTFR ciliary neurotrophic factor receptor [ Homo sapiens ]
Synonyms: CNTFR; ciliary neurotrophic factor receptor; MGC1774; CNTFR alpha; ciliary neurotrophic factor receptor; ciliary neurotrophic factor receptor alpha; OTTHUMP00000021270; OTTHUMP00000021271
Gene ID: 1271
mRNA Refseq: NM_001842
Protein Refseq: NP_001833
MIM: 118946
UniProt ID: P26992
Chromosome Location: 9p13
Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Function: ciliary neurotrophic factor receptor activity; receptor activity; receptor binding

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