Recombinant Human FLT4, His-tagged

• Cat.No.: FLT4-31718TH
• Product Overview: Human Recombinant Soluble VEGF Receptor 3 fragment fused with a carboxy-terminal 6X histidine-tag produced in baculovirus and expressed in Insect cells; 774 amino acids, 240 kDa.

Specification

• Description: This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.
• Conjugation: HIS
• Tissue specificity: Placenta, lung, heart, and kidney, does not seem to be expressed in pancreas and brain.
• Form: Lyophilised:Reconstitute in sterile water not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 1X PBS
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.Contains 7 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain.

Gene Information

• Gene Name: FLT4 fms-related tyrosine kinase 4 [ Homo sapiens ]
• Official Symbol: FLT4
• Synonyms: FLT4; fms-related tyrosine kinase 4; vascular endothelial growth factor receptor 3; PCL; VEGFR3
• Gene ID: 2324
• mRNA Refseq: NM_002020
• Protein Refseq: NP_002011
• MIM: 136352
• Uniprot ID: P35916
• Chromosome Location: 5q34-q35
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Focal adhesion, organism-specific biosystem; Focal adhesion, conserved biosystem; Signal Transduction, organism-specific biosystem
• Function: ATP binding; growth factor binding; nucleotide binding; protein binding; protein phosphatase binding