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Recombinant Human HDAC8, His-tagged

Cat.No. : HDAC8-27529TH
Product Overview : Recombinant full length protein (Human), C-terminal His tag.
  • Specification
  • Gene Information
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Description : Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
Conjugation : HIS
Tissue specificity : Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney.
Biological activity : 10 U/ug. One U =1 pmol/min, Assay condition: 25 mM Tris/Cl,pH8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 100 uM Biomol substrate (Catalog number KI-178), and 15 ng/ul HDAC8. Incubation condition: 60 min at 30oC.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Glycerol, 50mM Tris HCl, 138mM Sodium chloride, pH 8
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the histone deacetylase family. HD type 1 subfamily.
Gene Name : HDAC8 histone deacetylase 8 [ Homo sapiens ]
Official Symbol : HDAC8
Synonyms : HDAC8; histone deacetylase 8; HDACL1, histone deacetylase like 1; RPD3;
Gene ID : 55869
mRNA Refseq : NM_001166418
Protein Refseq : NP_001159890
MIM : 300269
Uniprot ID : Q9BY41
Chromosome Location : Xq13
Pathway : Cell cycle, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem;
Function : NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; histone deacetylase activity (H3-K16 spe;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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