"ICOS" Related Products


Recombinant Human ICOS protein

Cat.No.: ICOS-1628H
Product Overview: Recombinant Human ICOS was expressed in NS0.
Source: NS0
Species: Human
Form: This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Bio-activity: The biological activity of Human ICOS was determined by the ability to inhibit human T cell proliferation induced by rhB7H2/Fc Chimera in the presence of antiCD3. Wang, S. et al. (2000) Blood 96:2808. The expected ED50 is 1 - 4 μg/ml in the presence of 3 μg/ml rhB7H2/Fc Chimera and antiCD3 immobilized at 20 ng/ml.
Molecular Mass: The predicted molecular weight of Recombinant Human ICOS is Mr 40.3 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 50-60 kDa.
AA Sequence: eingsanyem fifhnggvqi lckypdivqq fkmqllkggq ilcdltktkg sgntvsiksl kfchsqlsnn svsfflynld hshanyyfcn lsifdpppfk vtltggylhi yesqlccqlk fiegrmdpks cdkthtcppc papellggps vflfppkpkd tlmisrtpev tcvvvdvshe dpevkfnwyv dgvevhnakt kpreeqynst yrvvsvltvl hqdwlngkey kckvsnkalp apiektiska kgqprepqvy tlppsrdelt knqvsltclv kgfypsdiav ewesngqpen nykttppvld sdgsfflysk ltvdksrwqq gnvfscsvmh ealhnhytqk slslspgk
Endotoxin: <1.0 EU/µg as determined by the LAL method
Purity: >90% by SDS-PAGE and analyzed by silver stain.
Storage: This lyophilized protein is stable for six to twelve months when stored desiccated at -20 centigrade to -70 centigrade. After aseptic reconstitution, this protein may be stored at 2 centigrade to 8 centigrade for one month or at -20 centigrade to -70 centigrade in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name: ICOS inducible T-cell co-stimulator [ Homo sapiens ]
Official Symbol: ICOS
Synonyms: ICOS; inducible T-cell co-stimulator; inducible T-cell costimulator; activation inducible lymphocyte immunomediatory molecule; AILIM; CD278; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule; CVID1; MGC39850;
Gene ID: 29851
mRNA Refseq: NM_012092
Protein Refseq: NP_036224
MIM: 604558
UniProt ID: Q9Y6W8
Chromosome Location: 2q33
Pathway: Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem;

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