ICOS-185H
Optional Service: Optional requirements on this protein
Product Overview :
The extracellular domain of human CD278 [ICOS] (aa 21-139) is fused to the N-terminus of the Fc region of human IgG1.
Description :
CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
Source :
CHO Cells
Species :
Human
Tag :
Fc
Form :
Lyophilized from 0.2μm-filtered solution in PBS.
Purity :
≥98% (SDS-PAGE)
Stability :
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Storage :
Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.