Recombinant Human ICOS, Fc-tagged
Cat.No. : | ICOS-185H |
Product Overview : | The extracellular domain of human CD278 [ICOS] (aa 21-139) is fused to the N-terminus of the Fc region of human IgG1. |
- Specification
- Gene Information
- Related Products
Description : | CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. |
Source : | CHO Cells |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Purity : | ≥98% (SDS-PAGE) |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles. |
Gene Name : | ICOS inducible T-cell co-stimulator [ Homo sapiens ] |
Official Symbol : | ICOS |
Synonyms : | ICOS; inducible T-cell co-stimulator; inducible T-cell costimulator; activation inducible lymphocyte immunomediatory molecule; AILIM; CD278; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule; CVID1; MGC39850; |
Gene ID : | 29851 |
mRNA Refseq : | NM_012092 |
Protein Refseq : | NP_036224 |
MIM : | 604558 |
UniProt ID : | Q9Y6W8 |
Chromosome Location : | 2q33 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; |
Products Types
◆ Recombinant Protein | ||
ICOS-1283R | Recombinant Rat ICOS protein(Met1-Leu142), hFc-tagged | +Inquiry |
ICOS-1248M | Acitve Recombinant Mouse ICOS protein(Met1-Gln135), His-tagged | +Inquiry |
Icos-6951M | Active Recombinant Mouse Icos protein(Met1-Leu142), hFc-tagged | +Inquiry |
ICOS-055H | Recombinant Human ICOS Protein, His-tagged | +Inquiry |
ICOS-2008R | Recombinant Rhesus Macaque ICOS Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ICOS-2444HCL | Recombinant Human ICOS cell lysate | +Inquiry |
ICOS-1195RCL | Recombinant Rat ICOS cell lysate | +Inquiry |
ICOS-1724MCL | Recombinant Mouse ICOS cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket