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Recombinant Human ITGAV protein

Cat.No. : ITGAV-26862TH
Product Overview : Recombinant Human ITGAV was expressed in Wheat Germ.
  • Specification
  • Gene Information
  • Related Products
Description : The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.
Source : Wheat Germ
Species : Human
Form : 25 mM Tris-HCl of pH8.0 containing 2% glycerol.
Molecular Mass : 116 kDa
AA Sequence : MAFPPRRRLRLGPRGLPLLLSGLLL PLCRAFNLDVDSPAEYSGPEGSYFG FAVDFFVPSASSQMFLLVGAPKANT TQPGIVEGGQVLKCDWSSTRRCQPI EFDATGNRDYAKDDPLEFKSHQWFG ASVRSKQDKILACAPLYHWRTEMKQ EREPVGTCFLQDGTKTVEYAPCRSQ DIDADGQGFCQGGFSIDFTKADRVL LGGPGSFYWQGQLISDQVAEIVSKY DPNVYSIKYNNQLATRTAQAIFDDS YLGYSVAVGDFNGDGIDDFVSGVPR AARTLGMVYIYDGKNMSSLYNFTGE QMAAYFGFSVAATDINGDDYADVFI GAPLFMDRGSDGKLQEVGQVSVSLQ RASGDFQTTKLNGFEVFARFGSAIA PLGDLDQDGFNDIAIAAPYGGEDKK GIVYIFNGRSTGLNAVPSQILEGQW AARSMPPSFGYSMKGATDIDKNGYP DLIVGAFGVDRAILYRARPVITVNA GLEVYPSILNQDNKTCSLPGTALKV SCFNVRFCLKADGKGVLPRKLNFQV ELLLDKLKQKGAIRRALFLYSRSPS HSKNMTISRGGLMQCEELIAYLRDE SEFRDKLTPITIFMEYRLDYRTAAD TTGLQPILNQFTPANISRQAHILLD CGEDNVCKPKLEVSVDSDQKKIYIG DDNPLTLIVKAQNQGEGAYEAELIV SIPLQADFIGVVRNNEALARLSCAF KTENQTRQVVCDLGNPMKAGTQLLA GLRFSVHQQSEMDTSVKFDLQIQSS NLFDKVSPVVSHKVDLAVLAAVEIR GVSSPDHIFLPIPNWEHKENPETEE DVGPVVQHIYELRNNGPSSFSKAML HLQWPYKYNNNTLLYILHYDIDGPM NCTSDMEINPLRIKISSLQTTEKND TVAGQGERDHLITKRDLALSEGDIH TLGCGVAQCLKIVCQVGRLDRGKSA ILYVKSLLWTETFMNKENQNHSYSL KSSASFNVIEFPYKNLPIEDITNST LVTTNVTWGIQPAPMPVPVWVIILA VLAGLLLLAVLVFVMYRMGFFKRVR PPQEEQEREQLQPHENGEGNSET
Applications : Antibody Production; Functional Study: Recommended usage only, not validated yet; Compound Screening: Recommended usage only, not validated yet.
Notes : Heating may cause protein aggregation. Please do not heat this product before electrophoresis. Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Gene Name : ITGAV integrin, alpha V [ Homo sapiens ]
Official Symbol : ITGAV
Synonyms : ITGAV; integrin, alpha V; antigen identified by monoclonal L230 , integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) , MSK8, vitronectin receptor , VNRA, VTNR; integrin alpha-V; CD51; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); MSK8; VNRA; VTNR; DKFZp686A08142;
Gene ID : 3685
mRNA Refseq : NM_002210
Protein Refseq : NP_002201
MIM : 193210
UniProt ID : P06756
Chromosome Location : 2q31-q32
Pathway : Adaptive Immune System, organism-specific biosystem; Antigen processing-Cross presentation, organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Axon guidance, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem;
Function : contributes_to insulin-like growth factor I binding; contributes_to opsonin binding; protein binding; protein kinase C alpha binding; contributes_to protein kinase C binding; receptor activity; transforming growth factor beta binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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