"KDM1A" Related Products


Recombinant Human KDM1A

Cat.No.: KDM1A-29892TH
Product Overview: Recombinant fragment corresponding to amino acids 158-852 of Human KDM1 / LSD1 with N-terminal proprietary tag, 103 kDa.
Description: This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
Source: E. coli
Tissue specificity: Ubiquitously expressed.
Biological activity: Specific Activity: 0.82 pmole/min/μg.Assay buffer: 50 mM sodium phosphate, pH 7.4, 70 uM dimethylated H3-K4 peptide and 8 ng/ul recombinant KDM1 / LSD1, 30 min at 37°C.
Form: Liquid
Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 0.05% Tween 20, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0
Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities: Belongs to the flavin monoamine oxidase family.Contains 1 SWIRM domain.
Gene Name: KDM1A lysine (K)-specific demethylase 1A [ Homo sapiens ]
Official Symbol: KDM1A
Synonyms: KDM1A; lysine (K)-specific demethylase 1A; amine oxidase (flavin containing) domain 2 , AOF2, KDM1, lysine (K) specific demethylase 1; lysine-specific histone demethylase 1A; BHC110; KIAA0601; LSD1;
Gene ID: 23028
mRNA Refseq: NM_001009999
Protein Refseq: NP_001009999
MIM: 609132
Uniprot ID: O60341
Chromosome Location: 1p36.12
Pathway: Coregulation of Androgen receptor activity, organism-specific biosystem; Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Hemostasis, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem;
Function: MyoD binding; androgen receptor binding; chromatin binding; demethylase activity; enzyme binding;

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