Recombinant Human KRT81 KRT81-28044TH

Recombinant Human KRT81

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Recombinant Human KRT81

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Cat.No. : KRT81-28044TH
Product Overview : Recombinant full length Human KRT81 with N terminal proprietary tag; Predicted MW 48.33 kDa
Description : The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.
Protein length : 202 amino acids
Molecular Weight : 48.330kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla. Expressed in malignant lymph node tissue in breast carcinoma ti
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the intermediate filament family.
Gene Name : KRT81 keratin 81 [ Homo sapiens ]
Official Symbol : KRT81
Synonyms : KRT81; keratin 81; keratin, hair, basic, 1 , KRTHB1; keratin, type II cuticular Hb1; hard keratin type II 1; Hb 1;
Gene ID : 3887
mRNA Refseq : NM_002281
Protein Refseq : NP_002272
MIM : 602153
Uniprot ID : Q14533
Chromosome Location : 12q13
Function : protein binding; structural molecule activity;

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