Native Human LEP
Cat.No. : | LEP-27641TH |
Product Overview : | Human Leptin |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. |
Source : | E. coli |
Form : | Lyophilised:Reconstitute in water to a concentration of 1.0-5.0 mg/ml. |
Storage : | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | Human Leptin is a 16 kDa protein containing 147 amino acid residues:MVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGLDFIPGL HPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLEN LRDLLHVLAFSKSCHLPWASGLETLDSLGGVLEASGY STEVVALSRLQGSLQDMLWQLDLSPGC |
Sequence Similarities : | Belongs to the leptin family. |
Gene Name : | LEP leptin [ Homo sapiens ] |
Official Symbol : | LEP |
Synonyms : | LEP; leptin; leptin (murine obesity homolog) , leptin (obesity homolog, mouse) , OB, OBS; |
Gene ID : | 3952 |
mRNA Refseq : | NM_000230 |
Protein Refseq : | NP_000221 |
Uniprot ID : | P41159 |
Chromosome Location : | 7q31 |
Pathway : | Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; |
Function : | growth factor activity; hormone activity; peptide hormone receptor binding; |
Products Types
◆ Recombinant Protein | ||
LEP-1088P | Recombinant Pig LEP Protein, His-tagged | +Inquiry |
Lep-342L | Active Recombinant Rat Lep Protein (147 aa) | +Inquiry |
LEP-1086H | Recombinant Horse LEP Protein, His-tagged | +Inquiry |
Lep-120M | Active Recombinant Mouse Lep Protein | +Inquiry |
Lep-202M | Recombinant Mouse Lep Protein | +Inquiry |
◆ Lysates | ||
LEP-4773HCL | Recombinant Human LEP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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