|Cat. No. :
||The functional IL-5 receptor is a heteromeric complex consisting of an alpha and beta subunit. The IL-5Rα chain is exclusively expressed by eosinophils, some basophils and murine B1 cells or B cell precursors. Like many other cytokine receptors, alternative splicing of the α-chain gene results in expression of either a membrane bound or soluble form of the α-chain. The soluble form does not lead to signal transduction and therefore has an antagonistic effect on IL-5 signaling. Both monomeric forms of IL-5Rα are low affinity receptors, while dimerization with the β-chain produces a high affinity receptor. In either case, the α-chain exclusively binds IL-5 and the intra-cellular portion of IL-5Rα is associated with Janus kinase (JAK) 2, a protein tyrosine-kinase essential in IL-5 signal transduction.Soluble IL-5Ralpha expression pattern in an eosinophil-associated disease such as nasal polyposis (NP).
||Sf 21 Insect Cells.
|State Of Matter :
||>97% by SDS Page and analyzed by silver stain.
||<1.0 EU/µg as determined by the LAL method.
|Molecular Weight :
||The predicted molecular weight of Recombinant Human IL-5 sRα is Mr 38 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 43 kDa.
|Storage And Stability :
||This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.