Recombinant Human Interleukin 5 Receptor, Alpha
Cat.No. : | IL5RA-1646H |
- Specification
- Gene Information
- Related Products
Cat. No. : | IL5RA-1646H |
Description : | The functional IL-5 receptor is a heteromeric complex consisting of an alpha and beta subunit. The IL-5Rα chain is exclusively expressed by eosinophils, some basophils and murine B1 cells or B cell precursors. Like many other cytokine receptors, alternative splicing of the α-chain gene results in expression of either a membrane bound or soluble form of the α-chain. The soluble form does not lead to signal transduction and therefore has an antagonistic effect on IL-5 signaling. Both monomeric forms of IL-5Rα are low affinity receptors, while dimerization with the β-chain produces a high affinity receptor. In either case, the α-chain exclusively binds IL-5 and the intra-cellular portion of IL-5Rα is associated with Janus kinase (JAK) 2, a protein tyrosine-kinase essential in IL-5 signal transduction.Soluble IL-5Ralpha expression pattern in an eosinophil-associated disease such as nasal polyposis (NP). |
Source : | Sf 21 Insect Cells. |
State Of Matter : | Lyophilized. |
Purity : | >97% by SDS Page and analyzed by silver stain. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Molecular Weight : | The predicted molecular weight of Recombinant Human IL-5 sRα is Mr 38 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 43 kDa. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
Gene Name : | IL5RA interleukin 5 receptor, alpha [ Homo sapiens ] |
Synonyms : | IL5RA; interleukin 5 receptor, alpha; CD125; CDw125; HSIL5R3; IL5R; MGC26560; CD125 antigen; OTTHUMP00000115373; OTTHUMP00000206893; OTTHUMP00000206896; interleukin 5 receptor type 3; interleukin-5 receptor alpha chain; interleukin-5 receptor alpha subunit; OTTHUMP00000115257; IL-5R-alpha |
Gene ID : | 3568 |
mRNA Refseq : | NM_000564 |
Protein Refseq : | NP_000555 |
MIM : | 147851 |
UniProt ID : | Q01344 |
Chromosome Location : | 3p26-p24 |
Pathway : | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Hematopoietic cell lineage |
Function : | interleukin-5 receptor activity; protein binding |
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◆ Lysates | ||
IL5RA-001MCL | Recombinant Mouse IL5RA cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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