"IL5RA" Related Products

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Recombinant Human Interleukin 5 Receptor, Alpha

Cat. No. : IL5RA-1646H
Description : The functional IL-5 receptor is a heteromeric complex consisting of an alpha and beta subunit. The IL-5Rα chain is exclusively expressed by eosinophils, some basophils and murine B1 cells or B cell precursors. Like many other cytokine receptors, alternative splicing of the α-chain gene results in expression of either a membrane bound or soluble form of the α-chain. The soluble form does not lead to signal transduction and therefore has an antagonistic effect on IL-5 signaling. Both monomeric forms of IL-5Rα are low affinity receptors, while dimerization with the β-chain produces a high affinity receptor. In either case, the α-chain exclusively binds IL-5 and the intra-cellular portion of IL-5Rα is associated with Janus kinase (JAK) 2, a protein tyrosine-kinase essential in IL-5 signal transduction.Soluble IL-5Ralpha expression pattern in an eosinophil-associated disease such as nasal polyposis (NP).
Source : Sf 21 Insect Cells.
State Of Matter : Lyophilized.
Purity : >97% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Molecular Weight : The predicted molecular weight of Recombinant Human IL-5 sRα is Mr 38 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 43 kDa.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name : IL5RA interleukin 5 receptor, alpha [ Homo sapiens ]
Synonyms : IL5RA; interleukin 5 receptor, alpha; CD125; CDw125; HSIL5R3; IL5R; MGC26560; CD125 antigen; OTTHUMP00000115373; OTTHUMP00000206893; OTTHUMP00000206896; interleukin 5 receptor type 3; interleukin-5 receptor alpha chain; interleukin-5 receptor alpha subunit; OTTHUMP00000115257; IL-5R-alpha
Gene ID : 3568
mRNA Refseq : NM_000564
Protein Refseq : NP_000555
MIM : 147851
UniProt ID : Q01344
Chromosome Location : 3p26-p24
Pathway : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Hematopoietic cell lineage
Function : interleukin-5 receptor activity; protein binding

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