||Recombinant fragment, corresponding to amino acids 182-808 of Human MCM3 with an N-terminal His tag; Predicted MWt 71kDa.
||The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.
||Lyophilised:Reconstitute with 84 μl aqua dest
||Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
||Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
|Sequences of amino acids:
||NPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVIL DDDLVDKAKPGDRVQVVGTYRCLPGKKGGYTSGTFRTV LIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFD QLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHI RGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSG VGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDK MSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAA ANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQM DPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILAT DDPNFSQEDQQDTQIYEKHDNLLHGTKKKKEKMVSAAF MKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSS DTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAE EAVELVQYAYFKKVLEKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMPQVH TPKTADSQETKESQKVELSESRLKAFKVALLDVFREAH AQSIGMNRLTESINRDSEEPFSSVEIQAALSKMQDDNQ VMVSEGIIFLI
||Belongs to the MCM family.Contains 1 MCM domain.