Recombinant Human MMP11, His-tagged

• Cat.No.: MMP11-27650TH
• Product Overview: Recombinant full length Human MMP11 with His and a proprietary tag; 702 amino acids with tag, MWt 79.8kDa.

Specification

• Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMPs, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Specifically expressed in stromal cells of breast carcinomas.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: 100mM ImidazoleConstituents: 0.5M Sodium chloride, 20mM Tris HCl, 1mM Beta mercaptoethanol, pH 8.0
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the peptidase M10A family.Contains 4 hemopexin-like domains.

Gene Information

• Gene Name: MMP11 matrix metallopeptidase 11 (stromelysin 3) [ Homo sapiens ]
• Official Symbol: MMP11
• Synonyms: MMP11; matrix metallopeptidase 11 (stromelysin 3); matrix metalloproteinase 11 (stromelysin 3) , STMY3; stromelysin-3
• Gene ID: 4320
• mRNA Refseq: NM_005940
• Protein Refseq: NP_005931
• MIM: 185261
• Uniprot ID: P24347
• Chromosome Location: 22q11.23
• Pathway: Matrix Metalloproteinases, organism-specific biosystem
• Function: calcium ion binding; metalloendopeptidase activity; peptidase activity; zinc ion binding