||Metalloproteinase purified from cell culture media of BHK cells transfected with Murine 105 kD Gelatinase (murine homologue of Human MMP9).
||Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
||Produced by normal alveolar macrophages and granulocytes.
||Preservative: NoneConstituents: 50% Glycerol, PBS, 250mM Sodium chloride, 0.6 % DMSO, pH 7.4
||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
||Belongs to the peptidase M10A family.Contains 3 fibronectin type-II domains.Contains 4 hemopexin-like domains.