Recombinant Human Platelet-Derived Growth Factor Receptor, Alpha Polypeptide

• Cat.No.: PDGFRA-1576H
• Product Overview: Recombinant Human PDGF alpha receptor extracellular domain is produced by genetically engineered Spodoptera frugiperdainsect cells (Sf9)infected with recombinant baculovirus, and purified by lectin affinity chromatography.

Specification

• Cat. No.: PDGFRA-1576H
• Description: TNFR1 belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-alpha or TNF-beta to TNFR1 initiates a signal transduction pathway that results in the activation of the transduction factor NFkB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis.
• Source: Sf9.
• Isotype: N/A.
• Purity: Over 85% pure by SDS gel electrophoresis.
• Formulation: 10 mM Tris-HCl, pH 7.0. Concentration: 0.50 mg protein/ml.
• Biological Activity: The material is able to bind the ligand (PDGF) as demonstrated by immobilizing the PDGF receptor extracellular domain and establishing competition of binding with radioiodinated PDGF.
• Stability: At least 2 months at -80°C.
• Storage: Store at -80°C.

Gene Information

• Gene Name: PDGFRA platelet-derived growth factor receptor, alpha polypeptide [ Homo sapiens ]
• Synonyms: PDGFRA; platelet-derived growth factor receptor, alpha polypeptide; CD140A; PDGFR2; MGC74795; RHEPDGFRA; Alpha-type platelet-derived growth factor receptor; EC 2.7.10.1; PDGF-R-alpha; CD140 antigen-like family member A; CD140a antigen
• Gene ID: 5156
• mRNA Refseq: NM_006206
• Protein Refseq: NP_006197
• MIM: 173490
• UniProt ID: P16234
• Chromosome Location: 4q12
• Pathway: Calcium signaling pathway; Colorectal cancer; Cytokine-cytokine receptor interaction; Endocytosis; Focal adhesion; Gap junction; Glioma; Pathways in cancer; Regulation of actin cytoskeleton; Signaling by PDGF
• Function: ATP binding; nucleotide binding; platelet-derived growth factor alpha-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; protein heterodimerization activity; receptor activity; transferase activity; vascular endothelial growth factor receptor activity