"PDGFRA" Related Products


Recombinant Human Platelet-Derived Growth Factor Receptor, Alpha Polypeptide

Cat. No. : PDGFRA-1576H
Product Overview : Recombinant Human PDGF alpha receptor extracellular domain is produced by genetically engineered Spodoptera frugiperdainsect cells (Sf9)infected with recombinant baculovirus, and purified by lectin affinity chromatography.
Description : TNFR1 belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-alpha or TNF-beta to TNFR1 initiates a signal transduction pathway that results in the activation of the transduction factor NFkB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis.
Source : Sf9.
Availability : Available.
Isotype : N/A.
Purity : Over 85% pure by SDS gel electrophoresis.
Formulation : 10 mM Tris-HCl, pH 7.0. Concentration: 0.50 mg protein/ml.
Biological Activity : The material is able to bind the ligand (PDGF) as demonstrated by immobilizing the PDGF receptor extracellular domain and establishing competition of binding with radioiodinated PDGF.
Stability : At least 2 months at -80°C.
Storage : Store at -80°C.
Gene Name : PDGFRA platelet-derived growth factor receptor, alpha polypeptide [ Homo sapiens ]
Synonyms : PDGFRA; platelet-derived growth factor receptor, alpha polypeptide; CD140A; PDGFR2; MGC74795; RHEPDGFRA; Alpha-type platelet-derived growth factor receptor; EC; PDGF-R-alpha; CD140 antigen-like family member A; CD140a antigen
Gene ID : 5156
mRNA Refseq : NM_006206
Protein Refseq : NP_006197
MIM : 173490
UniProt ID : P16234
Chromosome Location : 4q12
Pathway : Calcium signaling pathway; Colorectal cancer; Cytokine-cytokine receptor interaction; Endocytosis; Focal adhesion; Gap junction; Glioma; Pathways in cancer; Regulation of actin cytoskeleton; Signaling by PDGF
Function : ATP binding; nucleotide binding; platelet-derived growth factor alpha-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; protein heterodimerization activity; receptor activity; transferase activity; vascular endothelial growth factor receptor activity

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