Recombinant Human NPR2

• Cat.No.: NPR2-30369TH
• Product Overview: Recombinant fragment corresponding to amino acids 131-230 of Human Natriuretic Peptide Receptor B with an N terminal proprietary tag; Predicted MWt 36.63 kDa.

Specification

• Description: This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.
• Protein length: 100 amino acids
• Molecular Weight: 36.630kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: AKNDHYRTLVRTGPSAPKLGEFVVT LHGHFNWTARAALLYLDARTDDRPH YFTIEGVFEALQGSNLSVQHQVYAR EPGGPEQATHFIRANGRIVYICGPL
• Sequence Similarities: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.Contains 1 guanylate cyclase domain.Contains 1 protein kinase domain.

Gene Information

• Gene Name: NPR2 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) [ Homo sapiens ]
• Official Symbol: NPR2
• Synonyms: NPR2; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); acromesomelic dysplasia, Maroteaux type , AMDM, ANPRB, NPRB; atrial natriuretic peptide receptor 2; ANPb; GUCY2B
• Gene ID: 4882
• mRNA Refseq: NM_003995
• Protein Refseq: NP_003986
• MIM: 108961
• Uniprot ID: P20594
• Chromosome Location: 9p21-p12
• Pathway: Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; Vascular smooth muscle contraction, organism-specific biosystem; Vascular smooth muscle contraction, conserved biosystem
• Function: ATP binding; GTP binding; guanylate cyclase activity; hormone binding; identical protein binding