Recombinant Human PDE7B

• Cat.No.: PDE7B-30823TH
• Product Overview: Recombinant full length Human PDE7B with an N-terminal proprietary tag, expressed by Baculovirus in Sf9 insect cells; MWt 73 kDa.

Specification

• Description: The 3,5-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3,5-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.
• Protein length: 450 amino acids
• Molecular Weight: 73.000kDa inclusive of tags
• Source: Baculovirus
• Biological activity: The specific activity of PDE7B is determined to be 28 nmol/min/mg.
• Form: Liquid
• Purity: by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: PDE7B phosphodiesterase 7B [ Homo sapiens ]
• Official Symbol: PDE7B
• Synonyms: PDE7B; phosphodiesterase 7B; cAMP-specific 3,5-cyclic phosphodiesterase 7B
• Gene ID: 27115
• mRNA Refseq: NM_018945
• Protein Refseq: NP_061818
• MIM: 604645
• Uniprot ID: Q9NP56
• Chromosome Location: 6q23-q24
• Pathway: G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem
• Function: 3,5-cyclic-AMP phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity