Recombinant Human PDE8A
Cat.No. : | PDE8A-30226TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 32-121 of Human PDE8A, with an N-terminal proprietary tag, predicted MWt 35.53 kDa |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Protein length : | 90 amino acids |
Molecular Weight : | 35.530kDa inclusive of tags |
Source : | Wheat germ |
Tissue specificity : | Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon. |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | RLPQGQKTAALPRTRGAGLLESELR DGSGKKVAVADVQFGPMRFHQDQLQ VLLVFTKEDNQCNGFCRACEKAGFK CTVTKEAQAVLACFL |
Sequence Similarities : | Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.Contains 1 PAC (PAS-associated C-terminal) domain.Contains 1 PAS (PER-ARNT-SIM) domain. |
Gene Name : | PDE8A phosphodiesterase 8A [ Homo sapiens ] |
Official Symbol : | PDE8A |
Synonyms : | PDE8A; phosphodiesterase 8A; high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A; HsT19550; |
Gene ID : | 5151 |
mRNA Refseq : | NM_001243137 |
Protein Refseq : | NP_001230066 |
MIM : | 602972 |
Uniprot ID : | O60658 |
Chromosome Location : | 15q25.3 |
Pathway : | G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; |
Function : | 3,5-cyclic-AMP phosphodiesterase activity; 3,5-cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity; |
Products Types
◆ Recombinant Protein | ||
PDE8A-6592M | Recombinant Mouse PDE8A Protein, His (Fc)-Avi-tagged | +Inquiry |
PDE8A-3170R | Recombinant Rhesus Macaque PDE8A Protein, His (Fc)-Avi-tagged | +Inquiry |
PDE8A-12564M | Recombinant Mouse PDE8A Protein | +Inquiry |
PDE8A-5117Z | Recombinant Zebrafish PDE8A | +Inquiry |
PDE8A-1608H | Recombinant Human PDE8A, His-tagged | +Inquiry |
◆ Lysates | ||
PDE8A-3339HCL | Recombinant Human PDE8A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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