Recombinant Human PSMC6, T7 -tagged

• Cat.No.: PSMC6-31225TH
• Product Overview: Recombinant full length protein: Human PSMC6 fused with a T7 tag at N-terminus.

Specification

• Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.
• Conjugation: T7
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: 0.002% Sodium AzideConstituents: 0.1% Triton-X-100, 10mM Tris, pH 8.0
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the AAA ATPase family.

Gene Information

• Gene Name: PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 [ Homo sapiens ]
• Official Symbol: PSMC6
• Synonyms: PSMC6; proteasome (prosome, macropain) 26S subunit, ATPase, 6; 26S protease regulatory subunit 10B; p42
• Gene ID: 5706
• mRNA Refseq: NM_002806
• Protein Refseq: NP_002797
• MIM: 602708
• Uniprot ID: P62333
• Chromosome Location: 14q22.1
• Pathway: APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem
• Function: ATP binding; ATPase activity; hydrolase activity; nucleotide binding; protein binding