"PSMC6" Related Products

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Recombinant Human PSMC6, T7 -tagged

Cat.No.: PSMC6-31225TH
Product Overview: Recombinant full length protein: Human PSMC6 fused with a T7 tag at N-terminus.
Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.
Conjugation: T7
Source: E. coli
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: 0.002% Sodium AzideConstituents: 0.1% Triton-X-100, 10mM Tris, pH 8.0
Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities: Belongs to the AAA ATPase family.
Gene Name: PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 [ Homo sapiens ]
Official Symbol: PSMC6
Synonyms: PSMC6; proteasome (prosome, macropain) 26S subunit, ATPase, 6; 26S protease regulatory subunit 10B; p42;
Gene ID: 5706
mRNA Refseq: NM_002806
Protein Refseq: NP_002797
MIM: 602708
Uniprot ID: P62333
Chromosome Location: 14q22.1
Pathway: APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem;
Function: ATP binding; ATPase activity; hydrolase activity; nucleotide binding; protein binding;

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