||Recombinant fragment, corresponding to amino acids 883/1210 of Human PTPRS, was expressed in E coli using an N-terminal tag, MW 63 kDa.
||The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
||Detected in all tissues tested except for placenta and liver.
||Preservative: NoneConstituents: 30% Glycerol, 50mM Sodium chloride, 20mM MOPS, 0.25mM DTT, 0.1mM PMSF, pH 7.5
||Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
||Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.Contains 8 fibronectin type-III domains.Contains 3 Ig-like C2-type (immunoglobulin-like) domains.Contains 2 tyrosine-protein phosphatase domains.