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Recombinant Mouse Interleukin 1 Receptor, Type I

Cat. No. : Il1r1-1753M
Description : Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene. The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
Molecular Weight : The predicted molecular weight of Recombinant Mouse IL-1 RI is Mr 63.8 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 95-110 kDa.
Source : NSO Cells.
State Of Matter : Lyophilized.
Purity : >90% by SDS Page and analyzed by silver stain.
Endotoxin : <0.1 ng per 1 µg as determined by the LAL method.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
PDB rendering based on 1g0y. :

Gene Name : Il1r1 interleukin 1 receptor, type I [ Mus musculus ]
Synonyms : Il1r1; interleukin 1 receptor, type I; IL-iR; CD121a; CD121b; Il1r-1; MGC129154; IL-1 receptor alpha chain;IL-iR
Gene ID : 16177
mRNA Refseq : NM_001123382
Protein Refseq : NP_001116854
UniProt ID : P13504
Chromosome Location : 1 B; 1 19.5 cM
Pathway : Apoptosis; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; MAPK signaling pathway
Function : interleukin-1 receptor activity; interleukin-1, Type I, activating receptor activity; protein binding; receptor activity; signal transducer activity; transmembrane receptor activity

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