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Recombinant Mouse Interleukin 21 Receptor

Cat. No.: Il21r-1763M
Description: Interleukin 21 Receptor belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.
Molecular Weight: The predicted molecular weight of Recombinant Mouse IL-21 R is Mr 51.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 70-80 kDa.
Source: NSO Cells.
State Of Matter: Lyophilized.
Purity: >95% by SDS Page and analyzed by silver stain.
Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: Il21r interleukin 21 receptor [ Mus musculus ]
Synonyms: Il21r; interleukin 21 receptor; NILR
Gene ID: 60504
mRNA Refseq: NM_021887
Protein Refseq: NP_068687
UniProt ID: Q9JHX3
Chromosome Location: 7 F4
Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Function: cytokine receptor activity; receptor activity; transmembrane receptor activity

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