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Recombinant Rat Jagged 1

Cat. No. : Jag1-1795R
Description : Jagged 1 (JAG1) is a cell surface protein that functions in an embryologically important signaling pathway, known as the Notch signaling pathway, which is a highly conserved cell signaling system. JAG1 plays an essential role in tissue formation during embryonic development of primitive organisms. JAG1 is a strong candidate gene for Alagille syndrome (AGS) which is an autosomal dominant disorder with developmental abnormalities affecting the liver, heart, eyes, vertebrae, and craniofacial region.
Molecular Weight : The predicted molecular weight of Recombinant Rat Jagged 1 is Mr 141.7 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 180 kDa.
Source : NSO Cells.
State Of Matter : Lyophilized.
Purity : >90% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : Jag1 jagged 1 [ Rattus norvegicus ]
Synonyms : Jag1; jagged 1;ligand responsible for activating Notch1
Gene ID : 29146
mRNA Refseq : NM_019147
Protein Refseq : NP_062020
UniProt ID : Q63722
Chromosome Location : 3q36
Pathway : Notch signaling pathway
Function : Notch binding; calcium ion binding; protein binding

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