Recombinant Rat Jagged 1

• Cat.No.: Jag1-1795R

Specification

• Cat. No.: Jag1-1795R
• Description: Jagged 1 (JAG1) is a cell surface protein that functions in an embryologically important signaling pathway, known as the Notch signaling pathway, which is a highly conserved cell signaling system. JAG1 plays an essential role in tissue formation during embryonic development of primitive organisms. JAG1 is a strong candidate gene for Alagille syndrome (AGS) which is an autosomal dominant disorder with developmental abnormalities affecting the liver, heart, eyes, vertebrae, and craniofacial region.
• Molecular Weight: The predicted molecular weight of Recombinant Rat Jagged 1 is Mr 141.7 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 180 kDa.
• Source: Mammalian cells
• State Of Matter: Lyophilized.
• Purity: >90% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: Jag1 jagged 1 [ Rattus norvegicus ]
• Synonyms: Jag1; jagged 1;ligand responsible for activating Notch1
• Gene ID: 29146
• mRNA Refseq: NM_019147
• Protein Refseq: NP_062020
• UniProt ID: Q63722
• Chromosome Location: 3q36
• Pathway: Notch signaling pathway
• Function: Notch binding; calcium ion binding; protein binding