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Recombinant Mouse Matrix Metallopeptidase 9

Cat.No. : Mmp9-417M
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  • Gene Information
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Cat. No. : Mmp9-417M
Description : Matrix metallopeptidase 9, also known as MMP9, is a biological enzyme that is a member of the matrix metalloproteinases (MMPs). MMP9 is thought to play a critical role in tumor cell invasion, breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. MMP-9 is secreted from cells and, once activated, is thought to degrade collagen in the extracellular matrix. MMP-9 is one of the major proteases produced by osteoclasts and possibly plays a role in osteoclastic bone resorption.
Molecular Weight : The predicted molecular weight of Recombinant Mouse MMP-9 is Mr 78.4 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 105-110 kDa.
Source : Mammalian cells
State Of Matter : Solution.
Purity : >90% by SDS Page and analyzed by silver stain.
Formulation : Supplied as a 0.2 μm filtered solution of TCNB (50 mM Tris-HCl, pH 7.5, 10 mM CaCl2, 150 mM NaCl, 0.05% Brij 35) at a concentration of 0.2 mg/mL.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Biological Activity : The specific activity, measured with 10 μM ES001 and 20 ng enzyme in 100 μL of TCNB (50 mM Tris-HCl, pH 7.5, 10 mM CaCl2, 150 mM NaCl, 0.05% Brij 35) at room temperature, is > 1,500 pmoles/min/μg.
Storage And Stability : This protein is stable for one month when stored sterile at -20°Cor for three months when stored at -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name : Mmp9 matrix metallopeptidase 9 [ Mus musculus ]
Synonyms : Mmp9; matrix metallopeptidase 9; Clg4b; MMP-9; B/MMP9; AW743869; pro-MMP-9; Gel B; gelatinase B; 92kD gelatinase; 92kDa gelatinase; OTTMUSP00000001145; collagenase type IVB; 92kD type IV collagenase; 92kDa type IV collagenase; matrix metalloproteinase 9; EC 3.4.24.35
Gene ID : 17395
mRNA Refseq : NM_013599
Protein Refseq : NP_038627
UniProt ID : P41245
Chromosome Location : 2 H1-H2; 2 96.0 cM
Pathway : Bladder cancer; Leukocyte transendothelial migration; Pathways in cancer
Function : calcium ion binding; hydrolase activity; metal ion binding; metalloendopeptidase activity; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the consequences of dysregulated MMP9 expression in cancer progression? 02/13/2022

Dysregulated MMP9 expression is associated with cancer invasion and metastasis, as it enables tumor cells to degrade the extracellular matrix and invade surrounding tissues.

What is the impact of MMP9 polymorphisms on enzyme activity? 09/07/2021

Polymorphisms in the MMP9 gene can influence enzyme activity, potentially affecting the individual's susceptibility to certain diseases and the progression of pathological conditions.

Can you explain the role of MMP9 in tissue remodeling at the molecular level? 01/17/2020

MMP9 facilitates tissue remodeling by cleaving structural proteins in the extracellular matrix, such as collagen and gelatin, leading to changes in tissue architecture.

What is the role of MMP9 in the breakdown of the blood-brain barrier during neurological disorders? 11/14/2019

MMP9 contributes to the breakdown of the blood-brain barrier by degrading tight junction proteins, potentially exacerbating neurological disorders and neuroinflammation.

How does MMP9 contribute to angiogenesis at the molecular level? 06/02/2018

MMP9 plays a role in angiogenesis by promoting the release and activation of growth factors sequestered in the extracellular matrix, facilitating the formation of new blood vessels.

Customer Reviews (3)

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Reviews
05/03/2020

    The superior quality of this recombined protein has significantly enhanced the precision of our research outcomes.

    08/15/2019

      Fast shipping! Ordered this product, and it arrived well-packaged and ready for use in our experiments.

      01/21/2018

        Customer service went above and beyond to accommodate our specific needs, ensuring a smooth purchasing experience.

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