Recombinant Human SLIT2

• Cat.No.: SLIT2-30441TH
• Product Overview: Recombinant fragment, corresponding to amino acids 27-1118 of Human Slit2; 1092 amino acids, 122kDa.

Specification

• Description: Slit2 is a member of the Slit family that signals through the Roundabout (Robo) receptor as a repellent for axon guidance and neuronal migration, and can also act as a chemoattractant to vascular endothelial cells and a chemotaxis inhibitor for leukocyte
• Tissue specificity: Fetal lung and kidney, and adult spinal cord. Weak expression in adult adrenal gland, thyroid, trachea and other tissues examined.
• Form: Lyophilised
• Purity: >95% by SDS-PAGE
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: ACPAQCSCSG STVDCHGLAL RSVPRNIPRN TERLDLNGNN ITRITKTDFA GLRHLRVLQL MENKISTIER GAFQDLKELE RLRLNRNHLQ LFPELLFLGT AKLYRLDLSE NQIQAIPRKA FRGAVDIKNL QLDYNQISCI EDGAFRALRD LEVLTLNNNN ITRLSVASFN HMPKLRTFRL HSNNLYCDCH LAWLSDWLRQ RPRVGLYTQC MGPSHLRGHN VAEVQKREFV CSGHQSFMAP SCSVLHCPAA CTCSNNIVDC RGKGLTEIPT NLPETITEIR LEQNTIKVIP PGAFSPYKKL RRIDLSNNQI SELAPDAFQG LRSLNSLVLY GNKITELPKS LFEGLFSLQL LLLNANKINC LRVDAFQDLH NLNLLSLYDN KLQTIAKGTF SPLRAIQTMH LAQNPFICDC HLKWLADYLH TNPIETSGAR CTSPRRLANK RIGQIKSKKF RCSAKEQYFI PGTEDYRSKL SGDCFADLAC PEKCRCEGTT VDCSNQKLNK IPEHIPQYTA ELRLNNNEFT VLEATGIFKK LPQLRKINFS NNKITDIEEG AFEGASGVNE ILLTSNRLEN VQHKMFKGLE SLKTLMLRSN RITCVGNDSF IGLSSVRLLS LYDNQITTVA PGAFDTLHSL STLNLLANPF NCNCYLAWLG EWLRKKRIVT GNPRCQKPYF LKEIPIQDVA IQDFTCDDGN DDNSCSPLSR CPTECTCLDT VVRCSNKGLK VLPKGIPRDV TELYLDGNQF TLVPKELSNY KHLTLIDLSN NRISTLSNQS FSNMTQLLTL ILSYNRLRCI PPRTFDGLKS LRLLSLHGND ISVVPEGAFN DLSALSHLAI GANPLYCDCN MQWLSDWVKS EYKEPGIARC AGPGEMADKL LLTTPSKKFT CQGPVDVNIL AKCNPCLSNP CKNDGTCNSD PVDFYRCTCP YGFKGQDCDV PIHACISNPC KHGGTCHLKE GEEDGFWCIC ADGFEGENCE VNVDDCEDND CENNSTCVDG INNYTCLCPP EYTGELCEEK LDFCAQDLNP CQHDSKCILT PKGFKCDCTP GYVGEHCDID FDDCQDNKCK NGAHCTDAVN GYTCICPEGY SGLFCEFSPP MV
• Sequence Similarities: Contains 1 CTCK (C-terminal cystine knot-like) domain.Contains 7 EGF-like domains.Contains 1 laminin G-like domain.Contains 23 LRR (leucine-rich) repeats.
• Publication:
  N-terminal Slit2 inhibits HIV-1 replication by regulating the actin cytoskeleton. (2013)
  Roles of Slit-Robo Signaling in Pathogenesis of Multiple Human Diseases: HIV-1 Infection, Vascular Endothelial Inflammation and Breast Cancer (2015)

Gene Information

• Gene Name: SLIT2 slit homolog 2 (Drosophila) [ Homo sapiens ]
• Official Symbol: SLIT2
• Synonyms: SLIT2; slit homolog 2 (Drosophila); SLIL3, slit (Drosophila) homolog 2; slit homolog 2 protein; Slit 2
• Gene ID: 9353
• mRNA Refseq: NM_004787
• Protein Refseq: NP_004778
• MIM: 603746
• Uniprot ID: O94813
• Chromosome Location: 4p15.2
• Pathway: Activation of Rac, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Axon guidance, organism-specific biosystem
• Function: GTPase inhibitor activity; Roundabout binding; calcium ion binding; heparin binding; laminin-1 binding